UDP-N-acetylglucosamine transferase subunit ALG14 homolog
1_MVCVL 6_ VLAAA 11_ AGAVA 16_ VFLIL 21_ RIWVV 26_ LRSMD 31_ VTPRE 36_ SLSIL 41_ VVAGS 46_ GGHTT 51_ EILRL 56_ LGSLS 61_ NAYSP 66_ RHYVI 71_ ADTDE 76_ MSANK 81_ INSFE 86_ LDRAD 91_ RDPSN 96_ MYTKY 101_ YIHRI 106_ PRSRE 111_ VQQSW 116_ PSTVF 121_ TTLHS 126_ MWLSF 131_ PLIHR 136_ VKPDL 141_ VLCNG 146_ PGTCV 151_ PICVS 156_ ALLLG 161_ ILGIK 166_ KVIIV 171_ YVESI 176_ CRVET 181_ LSMSG 186_ KILFH 191_ LSDYF 196_ IVQWP 201_ ALKEK 206_ YPKSV 211_YLGRI
1: Part of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharides are transferred from the lipid to nascent proteins by oligosaccharyltransferases. Functions as a protein-membrane adapter recruiting ALG13 at the cytoplasmic face of the endoplasmic reticulum, where the complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway