E3 ubiquitin-protein ligase TRIM11 (EC 2.3.2.27) (Protein BIA1) (RING finger protein 92) (RING-type E3 ubiquitin transferase TRIM11) (Tripartite motif-containing protein 11)
1_MAAPD 6_ LSTNL 11_ QEEAT 16_ CAICL 21_ DYFTD 26_ PVMTD 31_ CGHNF 36_ CRECI 41_ RRCWG 46_ QPEGP 51_ YACPE 56_ CRELS 61_ PQRNL 66_ RPNRP 71_ LAKMA 76_ EMARR 81_ LHPPS 86_ PVPQG 91_ VCPAH 96_ REPLA 101_ AFCGD 106_ ELRLL 111_ CAACE 116_ RSGEH 121_ WAHRV 126_ RPLQD 131_ AAEDL 136_ KAKLE 141_ KSLEH 146_ LRKQM 151_ QDALL 156_ FQAQA 161_ DETCV 166_ LWQKM 171_ VESQR 176_ QNVLG 181_ EFERL 186_ RRLLA 191_ EEEQQ 196_ LLQRL 201_ EEEEL 206_ EVLPR 211_ LREGA 216_ AHLGQ 221_ QSAHL 226_ AELIA 231_ ELEGR 236_ CQLPA 241_ LGLLQ 246_ DIKDA 251_ LRRVQ 256_ DVKLQ 261_ PPEVV 266_ PMELR 271_ TVCRV 276_ PGLVE 281_ TLRRF 286_ RGDVT 291_ LDPDT 296_ ANPEL 301_ ILSED 306_ RRSVQ 311_ RGDLR 316_ QALPD 321_ SPERF 326_ DPGPC 331_ VLGQE 336_ RFTSG 341_ RHYWE 346_ VEVGD 351_ RTSWA 356_ LGVCR 361_ ENVNR 366_ KEKGE 371_ LSAGN 376_ GFWIL 381_ VFLGS 386_ YYNSS 391_ ERALA 396_ PLRDP 401_ PRRVG 406_ IFLDY 411_ EAGHL 416_ SFYSA 421_ TDGSL 426_ LFIFP 431_ EIPFS 436_ GTLRP 441_ LFSPL 446_ SSSPT 451_ PMTIC 456_ RPKGG 461_SGDTL
1: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX (By similarity). Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis (By similarity). May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences (By similarity). May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (By similarity). Mediates MED15 ubiquitination leading to proteasomal degradation (PubMed:16904669). May contribute to the innate restriction of retroviruses (PubMed:18248090). Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression (PubMed:18248090). Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain (PubMed:18248090). May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle (PubMed:18248090). Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2 (PubMed:27498865). Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (PubMed:27498865)