Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217)
1_MGAAR 6_ SPPSA 11_ VPGPL 16_ LGLLL 21_ LLLGV 26_ LAPGG 31_ ASLRL 36_ LDHRA 41_ LVCSQ 46_ PGLNC 51_ TVKNS 56_ TCLDD 61_ SWIHP 66_ RNLTP 71_ SSPKD 76_ LQIQL 81_ HFAHT 86_ QQGDL 91_ FPVAH 96_ IEWTL 101_ QTDAS 106_ ILYLE 111_ GAELS 116_ VLQLN 121_ TNERL 126_ CVRFE 131_ FLSKL 136_ RHHHR 141_ RWRFT 146_ FSHFV 151_ VDPDQ 156_ EYEVT 161_ VHHLP 166_ KPIPD 171_ GDPNH 176_ QSKNF 181_ LVPDC 186_ EHARM 191_ KVTTP 196_ CMSSG 201_ SLWDP 206_ NITVE 211_ TLEAH 216_ QLRVS 221_ FTLWN 226_ ESTHY 231_ QILLT 236_ SFPHM 241_ ENHSC 246_ FEHMH 251_ HIPAP 256_ RPEEF 261_ HQRSN 266_ VTLTL 271_ RNLKG 276_ CCRHQ 281_ VQIQP 286_ FFSSC 291_ LNDCL 296_ RHSAT 301_ VSCPE 306_ MPDTP 311_ EPIPD 316_ YMPLW 321_ VYWFI 326_ TGISI 331_ LLVGS 336_ VILLI 341_ VCMTW 346_ RLAGP 351_ GSEKY 356_ SDDTK 361_ YTDGL 366_ PAADL 371_ IPPPL 376_ KPRKV 381_ WIIYS 386_ ADHPL 391_ YVDVV 396_ LKFAQ 401_ FLLTA 406_ CGTEV 411_ ALDLL 416_ EEQAI 421_ SEAGV 426_ MTWVG 431_ RQKQE 436_ MVESN 441_ SKIIV 446_ LCSRG 451_ TRAKW 456_ QALLG 461_ RGAPV 466_ RLRCD 471_ HGKPV 476_ GDLFT 481_ AAMNM 486_ ILPDF 491_ KRPAC 496_ FGTYV 501_ VCYFS 506_ EVSCD 511_ GDVPD 516_ LFGAA 521_ PRYPL 526_ MDRFE 531_ EVYFR 536_ IQDLE 541_ MFQPG 546_ RMHRV 551_ GELSG 556_ DNYLR 561_ SPGGR 566_ QLRAA 571_ LDRFR 576_ DWQVR 581_ CPDWF 586_ ECENL 591_ YSADD 596_ QDAPS 601_ LDEEV 606_ FEEPL 611_ LPPGT 616_ GIVKR 621_ APLVR 626_ EPGSQ 631_ ACLAI 636_ DPLVG 641_ EEGGA 646_ AVAKL 651_ EPHLQ 656_ PRGQP 661_ APQPL 666_ HTLVL 671_ AAEEG 676_ ALVAA 681_ VEPGP 686_ LADGA 691_ AVRLA 696_ LAGEG 701_ EACPL 706_ LGSPG 711_ AGRNS 716_ VLFLP 721_ VDPED 726_ SPLGS 731_ STPMA 736_ SPDLL 741_ PEDVR 746_ EHLEG 751_ LMLSL 756_ FEQSL 761_ SCQAQ 766_ GGCSR 771_ PAMVL 776_ TDPHT 781_ PYEEE 786_ QRQSV 791_ QSDQG 796_ YISRS 801_ SPQPP 806_ EGLTE 811_ MEEEE 816_ EEEQD 821_ PGKPA 826_ LPLSP 831_ EDLES 836_ LRSLQ 841_ RQLLF 846_ RQLQK 851_ NSGWD 856_ TMGSE 861_SEGPS
1: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:24120361). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848)
2: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway