E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1)
1_MFSPD 6_ QENHP 11_ SKAPV 16_ KYGEL 21_ IVLGY 26_ NGSLP 31_ NGDRG 36_ RRKSR 41_ FALFK 46_ RPKAN 51_ GVKPS 56_ TVHIA 61_ CTPQA 66_ AKAIS 71_ NKDQH 76_ SISYT 81_ LSRAQ 86_ TVVVE 91_ YTHDS 96_ NTDMF 101_ QIGRS 106_ TESPI 111_ DFVVT 116_ DTVPG 121_ SQSNS 126_ DTQSV 131_ QSTIS 136_ RFACR 141_ IICER 146_ NPPFT 151_ ARIYA 156_ AGFDS 161_ SKNIF 166_ LGEKA 171_ AKWKT 176_ SDGQM 181_ DGLTT 186_ NGVLV 191_ MHPRN 196_ GFTED 201_ SKPGI 206_ WREIS 211_ VCGNV 216_ FSLRE 221_ TRSAQ 226_ QRGKM 231_ VEIET 236_ NQLQD 241_ GSLID 246_ LCGAT 251_ LLWRT 256_ AEGLS 261_ HTPTV 266_ KHLEA 271_ LRQEI 276_ NAARP 281_ QCPVG 286_ FNTLA 291_ FPSMK 296_ RKDVV 301_ DEKQP 306_ WVYLN 311_ CGHVH 316_ GYHNW 321_ GNKEE 326_ RDGKD 331_ RECPM 336_ CRSVG 341_ PYVPL 346_ WLGCE 351_ AGFYV 356_ DAGPP 361_ THAFS 366_ PCGHV 371_ CSEKT 376_ TAYWS 381_ QIPLP 386_ HGTHT 391_ FHAAC 396_ PFCAH 401_ QLAGE 406_ QGYIR 411_LIFQG
1: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:12496252, PubMed:17675297, PubMed:29883609, PubMed:30952868). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (PubMed:12496252, PubMed:17675297). Acts as a positive regulator of inflammatory response in microglia through activation of NF-kappa-B and MAP kinase (By similarity). Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Conjugates 'Lys-63'-linked ubiquitin chains to the adapter protein ASC/PYCARD, which in turn is crucial for NLRP3 inflammasome activation (PubMed:34706239). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). Following phosphorylation by ATM, catalyzes 'Lys-63'-linked ubiquitination of NBN, promoting DNA repair via homologous recombination (PubMed:30952868). Negatively regulates activation of the metabolic mTORC1 signaling pathway by mediating 'Lys-63'-linked ubiquitination of mTORC1-inhibitory protein TSC1 and thereby promoting TSC1/TSC2 complex stability (PubMed:33215753)