ATP-dependent DNA helicase DDX11 (EC 3.6.4.12) (CHL1-related protein 1) (hCHLR1) (DEAD/H-box protein 11) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2)
1_MANET 6_ QKVGA 11_ IHFPF 16_ PFTPY 21_ SIQED 26_ FMAEL 31_ YRVLE 36_ AGKIG 41_ IFESP 46_ TGTGK 51_ SLSLI 56_ CGALS 61_ WLRDF 66_ EQKKR 71_ EEEAR 76_ LLETG 81_ TGPLH 86_ DEKDE 91_ SLCLS 96_ SSCEG 101_ AAGTP 106_ RPAGE 111_ PAWVT 116_ QFVQK 121_ KEERD 126_ LVDRL 131_ KAEQA 136_ RRKQR 141_ EERLQ 146_ QLQHR 151_ VQLKY 156_ AAKRL 161_ RQEEE 166_ ERENL 171_ LRLSR 176_ EMLET 181_ GPEAE 186_ RLEQL 191_ ESGEE 196_ ELVLA 201_ EYESD 206_ EEKKV 211_ ASRVD 216_ EDEDD 221_ LEEEH 226_ ITKIY 231_ YCSRT 236_ HSQLA 241_ QFVHE 246_ VKKSP 251_ FGKDV 256_ RLVSL 261_ GSRQN 266_ LCVNE 271_ DVKSL 276_ GSVQL 281_ INDRC 286_ VDMQR 291_ SRHEK 296_ KKGAE 301_ EEKPK 306_ RRRQE 311_ KQAAC 316_ PFYNH 321_ EQMGL 326_ LRDEA 331_ LAEVK 336_ DMEQL 341_ LALGK 346_ EARAC 351_ PYYGS 356_ RLAIP 361_ AAQLV 366_ VLPYQ 371_ MLLHA 376_ ATRQA 381_ AGIRL 386_ QDQVV 391_ IIDEA 396_ HNLID 401_ TITGM 406_ HSVEV 411_ SGSQL 416_ CQAHS 421_ QLLQY 426_ VERYG 431_ KRLKA 436_ KNLMY 441_ LKQIL 446_ YLLEK 451_ FVAVL 456_ GGNIK 461_ QNPNT 466_ QSLSQ 471_ TGTEL 476_ KTIND 481_ FLFQS 486_ QIDNI 491_ NLFKV 496_ QRYCE 501_ KSMIS 506_ RKLFG 511_ FTERY 516_ GAVFS 521_ SREQP 526_ KLAGF 531_ QQFLQ 536_ SLQPR 541_ TTEAL 546_ AAPAD 551_ ESQAS 556_ TLRPA 561_ SPLMH 566_ IQGFL 571_ AALTT 576_ ANQDG 581_ RVILS 586_ RQGSL 591_ SQSTL 596_ KFLLL 601_ NPAVH 606_ FAQVV 611_ KECRA 616_ VVIAG 621_ GTMQP 626_ VSDFR 631_ QQLLA 636_ CAGVE 641_ AERVV 646_ EFSCG 651_ HVIPP 656_ DNILP 661_ LVICS 666_ GISNQ 671_ PLEFT 676_ FQKRE 681_ LPQMM 686_ DEVGR 691_ ILCNL 696_ CGVVP 701_ GGVVC 706_ FFPSY 711_ EYLRQ 716_ VHAHW 721_ EKGGL 726_ LGRLA 731_ ARKKI 736_ FQEPK 741_ SAHQV 746_ EQVLL 751_ AYSRC 756_ IQACG 761_ QERGQ 766_ VTGAL 771_ LLSVV 776_ GGKMS 781_ EGINF 786_ SDNLG 791_ RCVVM 796_ VGMPF 801_ PNIRS 806_ AELQE 811_ KMAYL 816_ DQTLS 821_ PRPGT 826_ PREGS 831_ GGEPV 836_ HEGRQ 841_ PVHRQ 846_ GHQAP 851_ EGFCQ 856_ RSAPG 861_ PAICP 866_ APCPG 871_ QAAGL 876_ DPSPC 881_ GGQSY 886_ LWPRH 891_ CCCAE 896_ VSPGE 901_ VGLFL 906_ MGNHT 911_ TAWRR 916_ ALPLS 921_ CPLET 926_ VFVVG 931_ VVCGD 936_ PVTKV 941_ KPRRR 946_ VWSPE 951_ CCQDP 956_ GTGVS 961_SRRRK
1: DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:10648783, PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Also shows ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (PubMed:26503245). Also cooperates with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772, PubMed:18499658, PubMed:20124417, PubMed:23116066, PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Also plays a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:18499658, PubMed:22102414, PubMed:9013641)
2: (Microbial infection) Required for bovine papillomavirus type 1 regulatory protein E2 loading onto mitotic chromosomes during DNA replication for the viral genome to be maintained and segregated