Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1)
1_MPEGP 6_ ELHLA 11_ SQFVN 16_ EACRA 21_ LVFGG 26_ CVEKS 31_ SVSRN 36_ PEVPF 41_ ESSAY 46_ RISAS 51_ ARGKE 56_ LRLIL 61_ SPLPG 66_ AQPQQ 71_ EPLAL 76_ VFRFG 81_ MSGSF 86_ QLVPR 91_ EELPR 96_ HAHLR 101_ FYTAP 106_ PGPRL 111_ ALCFV 116_ DIRRF 121_ GRWDL 126_ GGKWQ 131_ PGRGP 136_ CVLQE 141_ YQQFR 146_ ENVLR 151_ NLADK 156_ AFDRP 161_ ICEAL 166_ LDQRF 171_ FNGIG 176_ NYLRA 181_ EILYR 186_ LKIPP 191_ FEKAR 196_ SVLEA 201_ LQQHR 206_ PSPEL 211_ TLSQK 216_ IRTKL 221_ QNPDL 226_ LELCH 231_ SVPKE 236_ VVQLG 241_ GKGYG 246_ SESGE 251_ EDFAA 256_ FRAWL 261_ RCYGM 266_ PGMSS 271_ LQDRH 276_ GRTIW 281_ FQGDP 286_ GPLAP 291_ KGRKS 296_ RKKKS 301_ KATQL 306_ SPEDR 311_ VEDAL 316_ PPSKA 321_ PSRTR 326_ RAKRD 331_ LPKRT 336_ ATQRP 341_ EGTSL 346_ QQDPE 351_ APTVP 356_ KKGRR 361_ KGRQA 366_ ASGHC 371_ RPRKV 376_ KADIP 381_SLEPE
1: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC