AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1)
1_MDQPF 6_ TVNSL 11_ KKLAA 16_ MPDHT 21_ DVSLS 26_ PEERV 31_ RALSK 36_ LGCNI 41_ TISED 46_ ITPRR 51_ YFRSG 56_ VEMER 61_ MASVY 66_ LEEGN 71_ LENAF 76_ VLYNK 81_ FITLF 86_ VEKLP 91_ NHRDY 96_ QQCAV 101_ PEKQD 106_ IMKKL 111_ KEIAF 116_ PRTDE 121_ LKNDL 126_ LKKYN 131_ VEYQE 136_ YLQSK 141_ NKYKA 146_ EILKK 151_ LEHQR 156_ LIEAE 161_ RKRIA 166_ QMRQQ 171_ QLESE 176_ QFLFF 181_ EDQLK 186_ KQELA 191_ RGQMR 196_ SQQTS 201_ GLSEQ 206_ IDGSA 211_ LSCFS 216_ THQNN 221_ SLLNV 226_ FADQP 231_ NKSDA 236_ TNYAS 241_ HSPPV 246_ NRALT 251_ PAATL 256_ SAVQN 261_ LVVEG 266_ LRCVV 271_ LPEDL 276_ CHKFL 281_ QLAES 286_ NTVRG 291_ IETCG 296_ ILCGK 301_ LTHNE 306_ FTITH 311_ VIVPK 316_ QSAGP 321_ DYCDM 326_ ENVEE 331_ LFNVQ 336_ DQHDL 341_ LTLGW 346_ IHTHP 351_ TQTAF 356_ LSSVD 361_ LHTHC 366_ SYQLM 371_ LPEAI 376_ AIVCS 381_ PKHKD 386_ TGIFR 391_ LTNAG 396_ MLEVS 401_ ACKKK 406_ GFHPH 411_ TKEPR 416_ LFSIC 421_ KHVLV 426_ KDIKI 431_IVLDL
1: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443)