Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1)
1_MEAPE 6_ EPAPV 11_ RGGPE 16_ ATLEV 21_ RGSRC 26_ LRLSA 31_ FREEL 36_ RALLV 41_ LAGPA 46_ FLVQL 51_ MVFLI 56_ SFISS 61_ VFCGH 66_ LGKLE 71_ LDAVT 76_ LAIAV 81_ INVTG 86_ VSVGF 91_ GLSSA 96_ CDTLI 101_ SQTYG 106_ SQNLK 111_ HVGVI 116_ LQRSA 121_ LVLLL 126_ CCFPC 131_ WALFL 136_ NTQHI 141_ LLLFR 146_ QDPDV 151_ SRLTQ 156_ TYVTI 161_ FIPAL 166_ PATFL 171_ YMLQV 176_ KYLLN 181_ QGIVL 186_ PQIVT 191_ GVAAN 196_ LVNAL 201_ ANYLF 206_ LHQLH 211_ LGVIG 216_ SALAN 221_ LISQY 226_ TLALL 231_ LFLYI 236_ LGKKL 241_ HQATW 246_ GGWSL 251_ ECLQD 256_ WASFL 261_ RLAIP 266_ SMLML 271_ CMEWW 276_ AYEVG 281_ SFLSG 286_ ILGMV 291_ ELGAQ 296_ SIVYE 301_ LAIIV 306_ YMVPA 311_ GFSVA 316_ ASVRV 321_ GNALG 326_ AGDME 331_ QARKS 336_ STVSL 341_ LITVL 346_ FAVAF 351_ SVLLL 356_ SCKDH 361_ VGYIF 366_ TTDRD 371_ IINLV 376_ AQVVP 381_ IYAVS 386_ HLFEA 391_ LACTS 396_ GGVLR 401_ GSGNQ 406_ KVGAI 411_ VNTIG 416_ YYVVG 421_ LPIGI 426_ ALMFA 431_ TTLGV 436_ MGLWS 441_ GIIIC 446_ TVFQA 451_ VCFLG 456_ FIIQL 461_ NWKKA 466_ CQQAQ 471_ VHANL 476_ KVNNV 481_ PRSGN 486_ SALPQ 491_ DPLHP 496_ GCPEN 501_ LEGIL 506_ TNDVG 511_ KTGEP 516_ QSDQQ 521_ MRQEE 526_ PLPEH 531_ PQDGA 536_ KLSRK 541_ QLVLR 546_ RGLLL 551_ LGVFL 556_ ILLVG 561_ILVRF
1: Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:16330770, PubMed:17509534). Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable)