Tetraspanin-17 (Tspan-17) (F-box only protein 23) (Tetraspan protein SB134) (Transmembrane 4 superfamily member 17)
1_MPGKH 6_ QHFQE 11_ PEVGC 16_ CGKYF 21_ LFGFN 26_ IVFWV 31_ LGALF 36_ LAIGL 41_ WAWGE 46_ KGVLS 51_ NISAL 56_ TDLGG 61_ LDPVW 66_ LFVVV 71_ GGVMS 76_ VLGFA 81_ GCIGA 86_ LRENT 91_ FLLKF 96_ FSVFL 101_ GLIFF 106_ LELAT 111_ GILAF 116_ VFKDW 121_ IRDQL 126_ NLFIN 131_ NNVKA 136_ YRDDI 141_ DLQNL 146_ IDFAQ 151_ EYWSC 156_ CGARG 161_ PNDWN 166_ LNIYF 171_ NCTDL 176_ NPSRE 181_ RCGVP 186_ FSCCV 191_ RDPAE 196_ DVLNT 201_ QCGYD 206_ VRLKL 211_ ELEQQ 216_ GFIHT 221_ KGCVG 226_ QFEKW 231_ LQDNL 236_ IVVAG 241_ VFMGI 246_ ALLQI 251_ FGICL 256_ AQNLV 261_SDIKA
1: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:28600292, PubMed:37516108). Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration (PubMed:28600292)