THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84)
1_MSPTP 6_ PLFSL 11_ PEART 16_ RFTKS 21_ TREAL 26_ NNKNI 31_ KPLLS 36_ TFSQV 41_ PGSEN 46_ EKKCT 51_ LDQAF 56_ RGILE 61_ EEIIN 66_ HSSCE 71_ NVLAI 76_ ISLAI 81_ GGVTE 86_ GICTA 91_ STPFV 96_ LLGDV 101_ LDCLP 106_ LDQCD 111_ TIFTF 116_ VEKNV 121_ ATWKS 126_ NTFYS 131_ AGKNY 136_ LLRMC 141_ NDLLR 146_ RLSKS 151_ QNTVF 156_ CGRIQ 161_ LFLAR 166_ LFPLS 171_ EKSGL 176_ NLQSQ 181_ FNLEN 186_ VTVFN 191_ TNEQE 196_ STLGQ 201_ KHTED 206_ REEGM 211_ DVEEG 216_ EMGDE 221_ EAPTT 226_ CSIPI 231_ DYNLY 236_ RKFWS 241_ LQDYF 246_ RNPVQ 251_ CYEKI 256_ SWKTF 261_ LKYSE 266_ EVLAV 271_ FKSYK 276_ LDDTQ 281_ ASRKK 286_ MEELK 291_ TGGEH 296_ VYFAK 301_ FLTSE 306_ KLMDL 311_ QLSDS 316_ NFRRH 321_ ILLQY 326_ LILFQ 331_ YLKGQ 336_ VKFKS 341_ SNYVL 346_ TDEQS 351_ LWIED 356_ TTKSV 361_ YQLLS 366_ ENPPD 371_ GERFS 376_ KMVEH 381_ ILNTE 386_ ENWNS 391_ WKNEG 396_ CPSFV 401_ KERTS 406_ DTKPT 411_ RIIRK 416_ RTAPE 421_ DFLGK 426_ GPTKK 431_ ILMGN 436_ EELTR 441_ LWNLC 446_ PDNME 451_ ACKSE 456_ TREHM 461_ PTLEE 466_ FFEEA 471_ IEQAD 476_ PENMV 481_ ENEYK 486_ AVNNS 491_ NYGWR 496_ ALRLL 501_ ARRSP 506_ HFFQP 511_ TNQQF 516_ KSLPE 521_ YLENM 526_ VIKLA 531_ KELPP 536_ PSEEI 541_ KTGED 546_ EDEED 551_ NDALL 556_ KENES 561_ PDVRR 566_ DKPVT 571_ GEQIE 576_ VFANK 581_ LGEQW 586_ KILAP 591_ YLEMK 596_ DSEIR 601_ QIECD 606_ SEDMK 611_ MRAKQ 616_ LLVAW 621_ QDQEG 626_ VHATP 631_ ENLIN 636_ ALNKS 641_ GLSDL 646_ AESLT 651_NDNET
1: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B/UAP56 (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Regulates transcriptional elongation of a subset of genes (PubMed:22144908). Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity)
2: Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1
3: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production