Charged multivesicular body protein 6 (Chromatin-modifying protein 6) (Vacuolar protein sorting-associated protein 20) (Vps20) (hVps20)
1_MGNLF 6_ GRKKQ 11_ SRVTE 16_ QDKAI 21_ LQLKQ 26_ QRDKL 31_ RQYQK 36_ RIAQQ 41_ LERER 46_ ALARQ 51_ LLRDG 56_ RKERA 61_ KLLLK 66_ KKRYQ 71_ EQLLD 76_ RTENQ 81_ ISSLE 86_ AMVQS 91_ IEFTQ 96_ IEMKV 101_ MEGLQ 106_ FGNEC 111_ LNKMH 116_ QVMSI 121_ EEVER 126_ ILDET 131_ QEAVE 136_ YQRQI 141_ DELLA 146_ GSFTQ 151_ EDEDA 156_ ILEEL 161_ SAITQ 166_ EQIEL 171_ PEVPS 176_ EPLPE 181_ KIPEN 186_ VPVKA 191_ RPRQA 196_ELVAA
1: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes