U3 small nucleolar ribonucleoprotein protein IMP4 (U3 snoRNP protein IMP4) (Brix domain-containing protein 4)
1_MLRRE 6_ ARLRR 11_ EYLYR 16_ KAREE 21_ AQRSA 26_ QERKE 31_ RLRRA 36_ LEENR 41_ LIPTE 46_ LRREA 51_ LALQG 56_ SLEFD 61_ DAGGE 66_ GVTSH 71_ VDDEY 76_ RWAGV 81_ EDPKV 86_ MITTS 91_ RDPSS 96_ RLKMF 101_ AKELK 106_ LVFPG 111_ AQRMN 116_ RGRHE 121_ VGALV 126_ RACKA 131_ NGVTD 136_ LLVVH 141_ EHRGT 146_ PVGLI 151_ VSHLP 156_ FGPTA 161_ YFTLC 166_ NVVMR 171_ HDIPD 176_ LGTMS 181_ EAKPH 186_ LITHG 191_ FSSRL 196_ GKRVS 201_ DILRY 206_ LFPVP 211_ KDDSH 216_ RVITF 221_ ANQDD 226_ YISFR 231_ HHVYK 236_ KTDHR 241_ NVELT 246_ EVGPR 251_ FELKL 256_ YMIRL 261_ GTLEQ 266_ EATAD 271_ VEWRW 276_ HPYTN 281_ TARKR 286_VFLST
1: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)