Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Sphingosine N-acyltransferase CERS2) (EC 2.3.1.24) (Tumor metastasis-suppressor gene 1 protein) (Very-long-chain ceramide synthase CERS2) (EC 2.3.1.297)
1_MLQTL 6_ YDYFW 11_ WERLW 16_ LPVNL 21_ TWADL 26_ EDRDG 31_ RVYAK 36_ ASDLY 41_ ITLPL 46_ ALLFL 51_ IVRYF 56_ FELYV 61_ ATPLA 66_ ALLNI 71_ KEKTR 76_ LRAPP 81_ NATLE 86_ HFYLT 91_ SGKQP 96_ KQVEV 101_ ELLSR 106_ QSGLS 111_ GRQVE 116_ RWFRR 121_ RRNQD 126_ RPSLL 131_ KKFRE 136_ ASWRF 141_ TFYLI 146_ AFIAG 151_ MAVIV 156_ DKPWF 161_ YDMKK 166_ VWEGY 171_ PIQST 176_ IPSQY 181_ WYYMI 186_ ELSFY 191_ WSLLF 196_ SIASD 201_ VKRKD 206_ FKEQI 211_ IHHVA 216_ TIILI 221_ SFSWF 226_ ANYIR 231_ AGTLI 236_ MALHD 241_ SSDYL 246_ LESAK 251_ MFNYA 256_ GWKNT 261_ CNNIF 266_ IVFAI 271_ VFIIT 276_ RLVIL 281_ PFWIL 286_ HCTLV 291_ YPLEL 296_ YPAFF 301_ GYYFF 306_ NSMMG 311_ VLQLL 316_ HIFWA 321_ YLILR 326_ MAHKF 331_ ITGKL 336_ VEDER 341_ SDREE 346_ TESSE 351_ GEEAA 356_ AGGGA 361_ KSRPL 366_ ANGHP 371_ILNNN
1: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27) (PubMed:17977534, PubMed:18165233, PubMed:18541923, PubMed:19728861, PubMed:20937905, PubMed:22144673, PubMed:22661289, PubMed:26887952, PubMed:29632068). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (By similarity) (PubMed:17977534, PubMed:18165233, PubMed:18541923, PubMed:19728861, PubMed:20937905, PubMed:22144673, PubMed:22661289, PubMed:26887952, PubMed:29632068). Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions (By similarity)