Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)
1_MQREE 6_ KQLEA 11_ SLDAL 16_ LSQVA 21_ DLKNS 26_ LGSFI 31_ CKLEN 36_ EYGRL 41_ TWPSV 46_ LDSFA 51_ LLSGQ 56_ LNTLN 61_ KVLKH 66_ EKTPL 71_ FRNQV 76_ IIPLV 81_ LSPDR 86_ DEDLM 91_ RQTEG 96_ RVPVF 101_ SHEVV 106_ PDHLR 111_ TKPDP 116_ EVEEQ 121_ EKQLT 126_ TDAAR 131_ IGADA 136_ AQKQI 141_ QSLNK 146_ MCSNL 151_ LEKIS 156_ KEERE 161_ SESGG 166_ LRPNK 171_ QTFNP 176_ TDTNA 181_ LVAAV 186_ AFGKG 191_ LSNWR 196_ PSGSS 201_ GPGQA 206_ GQPGA 211_ GTILA 216_ GTSGL 221_ QQVQM 226_ AGAPS 231_ QQQPM 236_ LSGVQ 241_ MAQAG 246_ QPGKM 251_ PSGIK 256_ TNIKS 261_ASMHP
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins