Melanocortin-2 receptor accessory protein 2 (MC2R accessory protein 2)
1_MSAQR 6_ LISNR 11_ TSQQS 16_ ASNSD 21_ YTWEY 26_ EYYEI 31_ GPVSF 36_ EGLKA 41_ HKYSI 46_ VIGFW 51_ VGLAV 56_ FVIFM 61_ FFVLT 66_ LLTKT 71_ GAPHQ 76_ DNAES 81_ SEKRF 86_ RMNSF 91_ VSDFG 96_ RPLEP 101_ DKVFS 106_ RQGNE 111_ ESRSL 116_ FHCYI 121_ NEVER 126_ LDRAK 131_ ACHQT 136_ TALDS 141_ DVQLQ 146_ EAIRS 151_ SGQPE 156_ EELNR 161_ LMKFD 166_ IPNFV 171_ NTDQN 176_ YFGED 181_ DLLIS 186_ EPPIV 191_ LETKP 196_LSQTS
1: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo