tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.89) (mRNA-dihydrouridine synthase DUS3L) (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like)
1_MAEGT 6_ AEAPL 11_ ENGGG 16_ GDSGA 21_ GALER 26_ GVAPI 31_ KRQYL 36_ TTKEQ 41_ FHQFL 46_ EAKGQ 51_ EKTCR 56_ ETEVG 61_ DPAGN 66_ ELAEP 71_ EAKRI 76_ RLEDG 81_ QTADG 86_ QTEEA 91_ AEPGE 96_ QLQTQ 101_ KRARG 106_ QNKGR 111_ PHVKP 116_ TNYDK 121_ NRLCP 126_ SLIQE 131_ SAAKC 136_ FFGDR 141_ CRFLH 146_ DVGRY 151_ LETKP 156_ ADLGP 161_ RCVLF 166_ ETFGR 171_ CPYGV 176_ TCRFA 181_ GAHLR 186_ PEGQN 191_ LVQEE 196_ LAARG 201_ TQPPS 206_ IRNGL 211_ DKALQ 216_ QQLRK 221_ REVRF 226_ ERAEQ 231_ ALRRF 236_ SQGPT 241_ PAAAV 246_ PEGTA 251_ AEGAP 256_ RQENC 261_ GAQQV 266_ PAGPG 271_ TSTPP 276_ SSPVR 281_ TCGPL 286_ TDEDV 291_ VRLRP 296_ CEKKR 301_ LDIRG 306_ KLYLA 311_ PLTTC 316_ GNLPF 321_ RRICK 326_ RFGAD 331_ VTCGE 336_ MAVCT 341_ NLLQG 346_ QMSEW 351_ ALLKR 356_ HQCED 361_ IFGVQ 366_ LEGAF 371_ PDTMT 376_ KCAEL 381_ LSRTV 386_ EVDFV 391_ DINVG 396_ CPIDL 401_ VYKKG 406_ GGCAL 411_ MNRST 416_ KFQQI 421_ VRGMN 426_ QVLDV 431_ PLTVK 436_ IRTGV 441_ QERVN 446_ LAHRL 451_ LPELR 456_ DWGVA 461_ LVTLH 466_ GRSRE 471_ QRYTK 476_ LADWQ 481_ YIEEC 486_ VQAAS 491_ PMPLF 496_ GNGDI 501_ LSFED 506_ ANRAM 511_ QTGVT 516_ GIMIA 521_ RGALL 526_ KPWLF 531_ TEIKE 536_ QRHWD 541_ ISSSE 546_ RLDIL 551_ RDFTN 556_ YGLEH 561_ WGSDT 566_ QGVEK 571_ TRRFL 576_ LEWLS 581_ FLCRY 586_ VPVGL 591_ LERLP 596_ QRINE 601_ RPPYY 606_ LGRDY 611_ LETLM 616_ ASQKA 621_ ADWIR 626_ ISEML 631_ LGPVP 636_ PSFAF 641_LPKHK
1: Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:34556860). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs (PubMed:34556860). Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation (PubMed:34556860)