OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA)
1_MTILP 6_ KKKPP 11_ PPDAD 16_ PANEP 21_ PPPGP 26_ MPPAP 31_ RRGGG 36_ VGVGG 41_ GGTGV 46_ GGGDR 51_ DRDSG 56_ VVGAR 61_ PRASP 66_ PPQGP 71_ LPGPP 76_ GALHR 81_ WALAV 86_ PPGAV 91_ AGPRP 96_ QQASP 101_ PPCGG 106_ PGGPG 111_ GGPGD 116_ ALGAA 121_ AAGVG 126_ AAGVV 131_ VGVGG 136_ AVGVG 141_ GCCSG 146_ PGHSK 151_ RRRQA 156_ PGVGA 161_ VGGGS 166_ PEREE 171_ VGAGY 176_ NSEDE 181_ YEAAA 186_ ARIEA 191_ MDPAT 196_ VEQQE 201_ HWFEK 206_ ALRDK 211_ KGFII 216_ KQMKE 221_ DGACL 226_ FRAVA 231_ DQVYG 236_ DQDMH 241_ EVVRK 246_ HCMDY 251_ LMKNA 256_ DYFSN 261_ YVTED 266_ FTTYI 271_ NRKRK 276_ NNCHG 281_ NHIEM 286_ QAMAE 291_ MYNRP 296_ VEVYQ 301_ YSTGT 306_ SAVEP 311_ INTFH 316_ GIHQN 321_ EDEPI 326_ RVSYH 331_ RNIHY 336_ NSVVN 341_ PNKAT 346_ IGVGL 351_ GLPSF 356_ KPGFA 361_ EQSLM 366_ KNAIK 371_ TSEES 376_ WIEQQ 381_ MLEDK 386_ KRATD 391_ WEATN 396_ EAIEE 401_ QVARE 406_ SYLQW 411_ LRDQE 416_ KQARQ 421_ VRGPS 426_ QPRKA 431_ SATCS 436_ SATAA 441_ ASSGL 446_ EEWTS 451_ RSPRQ 456_ RSSAS 461_ SPEHP 466_ ELHAE 471_ LGMKP 476_ PSPGT 481_ VLALA 486_ KPPSP 491_ CAPGT 496_ SSQFS 501_ AGADR 506_ ATSPL 511_ VSLYP 516_ ALECR 521_ ALIQQ 526_ MSPSA 531_ FGLND 536_ WDDDE 541_ ILASV 546_ LAVSQ 551_ QEYLD 556_ SMKKN 561_ KVHRD 566_PPPDK
1: Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214)