E3 ubiquitin-protein transferase RMND5B (EC 2.3.2.27) (Protein RMD5 homolog B)
1_MEQCA 6_ CVERE 11_ LDKVL 16_ QKFLT 21_ YGQHC 26_ ERSLE 31_ ELLHY 36_ VGQLR 41_ AELAS 46_ AALQG 51_ TPLSA 56_ TLSLV 61_ MSQCC 66_ RKIKD 71_ TVQKL 76_ ASDHK 81_ DIHSS 86_ VSRVG 91_ KAIDR 96_ NFDSE 101_ ICGVV 106_ SDAVW 111_ DAREQ 116_ QQQIL 121_ QMAIV 126_ EHLYQ 131_ QGMLS 136_ VAEEL 141_ CQEST 146_ LNVDL 151_ DFKQP 156_ FLELN 161_ RILEA 166_ LHEQD 171_ LGPAL 176_ EWAVS 181_ HRQRL 186_ LELNS 191_ SLEFK 196_ LHRLH 201_ FIRLL 206_ AGGPA 211_ KQLEA 216_ LSYAR 221_ HFQPF 226_ ARLHQ 231_ REIQV 236_ MMGSL 241_ VYLRL 246_ GLEKS 251_ PYCHL 256_ LDSSH 261_ WAEIC 266_ ETFTR 271_ DACSL 276_ LGLSV 281_ ESPLS 286_ VSFAS 291_ GCVAL 296_ PVLMN 301_ IKAVI 306_ EQRQC 311_ TGVWN 316_ HKDEL 321_ PIEIE 326_ LGMKC 331_ WYHSV 336_ FACPI 341_ LRQQT 346_ SDSNP 351_ PIKLI 356_ CGHVI 361_ SRDAL 366_ NKLIN 371_ GGKLK 376_ CPYCP 381_ MEQNP 386_ADGKR
1: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972)