Vacuole membrane protein 1 (Transmembrane protein 49)
1_MAENG 6_ KNCDQ 11_ RRVAM 16_ NKEHH 21_ NGNFT 26_ DPSSV 31_ NEKKR 36_ REREE 41_ RQNIV 46_ LWRQP 51_ LITLQ 56_ YFSLE 61_ ILVIL 66_ KEWTS 71_ KLWHR 76_ QSIVV 81_ SFLLL 86_ LAVLI 91_ ATYYV 96_ EGVHQ 101_ QYVQR 106_ IEKQF 111_ LLYAY 116_ WIGLG 121_ ILSSV 126_ GLGTG 131_ LHTFL 136_ LYLGP 141_ HIASV 146_ TLAAY 151_ ECNSV 156_ NFPEP 161_ PYPDQ 166_ IICPD 171_ EEGTE 176_ GTISL 181_ WSIIS 186_ KVRIE 191_ ACMWG 196_ IGTAI 201_ GELPP 206_ YFMAR 211_ AARLS 216_ GAEPD 221_ DEEYQ 226_ EFEEM 231_ LEHAE 236_ SAQDF 241_ ASRAK 246_ LAVQK 251_ LVQKV 256_ GFFGI 261_ LACAS 266_ IPNPL 271_ FDLAG 276_ ITCGH 281_ FLVPF 286_ WTFFG 291_ ATLIG 296_ KAIIK 301_ MHIQK 306_ IFVII 311_ TFSKH 316_ IVEQM 321_ VAFIG 326_ AVPGI 331_ GPSLQ 336_ KPFQE 341_ YLEAQ 346_ RQKLH 351_ HKSEM 356_ GTPQG 361_ ENWLS 366_ WMFEK 371_ LVVVM 376_ VCYFI 381_ LSIIN 386_ SMAQS 391_ YAKRI 396_ QQRLN 401_SEEKT
1: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (PubMed:33850023, PubMed:33929485). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (PubMed:33850023, PubMed:33929485). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:28890335, PubMed:30093494, PubMed:30933966, PubMed:33850023, PubMed:33929485). Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed:31526472, PubMed:33850023). Modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). Plays an essential role in formation of cell junctions (PubMed:17724469). Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death (By similarity). Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity)
2: (Microbial infection) Host factor required for infection by all flaviviruses tested such as Zika virus and Yellow fever virus (PubMed:33338421). Probably required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles (PubMed:33338421)