E3 ubiquitin-protein ligase RNF185 (EC 2.3.2.27) (RING finger protein 185)
1_MASKG 6_ PSASA 11_ SPENS 16_ SAGGP 21_ SGSSN 26_ GAGES 31_ GGQDS 36_ TFECN 41_ ICLDT 46_ AKDAV 51_ ISLCG 56_ HLFCW 61_ PCLHQ 66_ WLETR 71_ PNRQV 76_ CPVCK 81_ AGISR 86_ DKVIP 91_ LYGRG 96_ STGQQ 101_ DPREK 106_ TPPRP 111_ QGQRP 116_ EPENR 121_ GGFQG 126_ FGFGD 131_ GGFQM 136_ SFGIG 141_ AFPFG 146_ IFATA 151_ FNIND 156_ GRPPP 161_ AVPGT 166_ PQYVD 171_ EQFLS 176_ RLFLF 181_ VALVI 186_MFWLL
1: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693). Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036). Protects cells from ER stress-induced apoptosis (PubMed:27485036). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521). Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS at 'Lys-173' and 'Lys-384', thereby promoting CGAS cyclic GMP-AMP synthase activity (PubMed:28273161). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521)