DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)
1_MNKLK 6_ SSQKD 11_ KVRQF 16_ MIFTQ 21_ SSEKT 26_ AVSCL 31_ SQNDW 36_ KLDVA 41_ TDNFF 46_ QNPEL 51_ YIRES 56_ VKGSL 61_ DRKKL 66_ EQLYN 71_ RYKDP 76_ QDENK 81_ IGIDG 86_ IQQFC 91_ DDLAL 96_ DPASI 101_ SVLII 106_ AWKFR 111_ AATQC 116_ EFSKQ 121_ EFMDG 126_ MTELG 131_ CDSIE 136_ KLKAQ 141_ IPKME 146_ QELKE 151_ PGRFK 156_ DFYQF 161_ TFNFA 166_ KNPGQ 171_ KGLDL 176_ EMAIA 181_ YWNLV 186_ LNGRF 191_ KFLDL 196_ WNKFL 201_ LEHHK 206_ RSIPK 211_ DTWNL 216_ LLDFS 221_ TMIAD 226_ DMSNY 231_ DEEGA 236_ WPVLI 241_ DDFVE 246_ FARPQ 251_IAGTK
1: Part of an E3 ubiquitin ligase complex for neddylation (PubMed:18826954). Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:19617556, PubMed:23201271, PubMed:23401859, PubMed:26906416). Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Also acts as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity)