SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (SWI/SNF complex 60 kDa subunit)
1_MAARA 6_ GFQSV 11_ APSGG 16_ AGASG 21_ GAGAA 26_ AALGP 31_ GGTPG 36_ PPVRM 41_ GPAPG 46_ QGLYR 51_ SPMPG 56_ AAYPR 61_ PGMLP 66_ GSRMT 71_ PQGPS 76_ MGPPG 81_ YGGNP 86_ SVRPG 91_ LAQSG 96_ MDQSR 101_ KRPAP 106_ QQIQQ 111_ VQQQA 116_ VQNRN 121_ HNAKK 126_ KKMAD 131_ KILPQ 136_ RIREL 141_ VPESQ 146_ AYMDL 151_ LAFER 156_ KLDQT 161_ IMRKR 166_ LDIQE 171_ ALKRP 176_ IKQKR 181_ KLRIF 186_ ISNTF 191_ NPAKS 196_ DAEDG 201_ EGTVA 206_ SWELR 211_ VEGRL 216_ LEDSA 221_ LSKYD 226_ ATKQK 231_ RKFSS 236_ FFKSL 241_ VIELD 246_ KDLYG 251_ PDNHL 256_ VEWHR 261_ TATTQ 266_ ETDGF 271_ QVKRP 276_ GDVNV 281_ RCTVL 286_ LMLDY 291_ QPPQF 296_ KLDPR 301_ LARLL 306_ GIHTQ 311_ TRPVI 316_ IQALW 321_ QYIKT 326_ HKLQD 331_ PHERE 336_ FVICD 341_ KYLQQ 346_ IFESQ 351_ RMKFS 356_ EIPQR 361_ LHALL 366_ MPPEP 371_ IIINH 376_ VISVD 381_ PNDQK 386_ KTACY 391_ DIDVE 396_ VDDTL 401_ KTQMN 406_ SFLLS 411_ TASQQ 416_ EIATL 421_ DNKIH 426_ ETIET 431_ INQLK 436_ TQREF 441_ MLSFA 446_ RDPQG 451_ FINDW 456_ LQSQC 461_ RDLKT 466_ MTDVV 471_ GNPEE 476_ ERRAE 481_ FYFQP 486_ WAQEA 491_ VCRYF 496_ YSKVQ 501_ QRRQE 506_LEQAL
1: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058, PubMed:8804307). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342). Interacts with AKIRIN2 (By similarity)