Palmitoyltransferase ZDHHC12 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 12) (DHHC-12) (Zinc finger DHHC domain-containing protein 12) (Zinc finger protein 400)
1_MAPWA 6_ LLSPG 11_ VLVRT 16_ GHTVL 21_ TWGIT 26_ LVLFL 31_ HDTEL 36_ RQWEE 41_ QGELL 46_ LPLTF 51_ LLLVL 56_ GSLLL 61_ YLAVS 66_ LMDPG 71_ YVNVQ 76_ PQPQE 81_ ELKEE 86_ QTAMV 91_ PPAIP 96_ LRRCR 101_ YCLVL 106_ QPLRA 111_ RHCRE 116_ CRRCV 121_ RRYDH 126_ HCPWM 131_ ENCVG 136_ ERNHP 141_ LFVVY 146_ LALQL 151_ VVLLW 156_ GLYLA 161_ WSGLR 166_ FFQPW 171_ GQWLR 176_ SSGLL 181_ FATFL 186_ LLSLF 191_ SLVAS 196_ LLLVS 201_ HLYLV 206_ ASNTT 211_ TWEFI 216_ SSHRI 221_ AYLRQ 226_ RPSNP 231_ FDRGL 236_ TRNLA 241_ HFFCG 246_ WPSGS 251_ WETLW 256_ AEEEE 261_EGSSP
1: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:36586411). Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering (By similarity). Thereby, indirectly regulates GABAergic synaptic transmission (By similarity). Negatively regulates NLRP3-driven inflammation. Catalyzes NLRP3 palmitoylation, leading to its degradation via the chaperone-mediated autophagy (CMA) process (PubMed:36586411, PubMed:39225180)