Ataxin-7-like protein 3B
1_MEEIS 6_ LANLD 11_ TNKLE 16_ AIAQE 21_ IYVDL 26_ IEDSC 31_ LGFCF 36_ EVHRA 41_ VKCGY 46_ FYLEF 51_ AETGS 56_ VKDFG 61_ IQPVE 66_ DKGAC 71_ RLPLC 76_ SLPGE 81_ PGNGP 86_ DQQLQ 91_RSPPE
1: By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3