Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L)
1_MDPTA 6_ GSKKE 11_ PGGGA 16_ ATEEG 21_ VNRIA 26_ VPKPP 31_ SIEEF 36_ SIVKP 41_ ISRGA 46_ FGKVY 51_ LGQKG 56_ GKLYA 61_ VKVVK 66_ KADMI 71_ NKNMT 76_ HQVQA 81_ ERDAL 86_ ALSKS 91_ PFIVH 96_ LYYSL 101_ QSANN 106_ VYLVM 111_ EYLIG 116_ GDVKS 121_ LLHIY 126_ GYFDE 131_ EMAVK 136_ YISEV 141_ ALALD 146_ YLHRH 151_ GIIHR 156_ DLKPD 161_ NMLIS 166_ NEGHI 171_ KLTDF 176_ GLSKV 181_ TLNRD 186_ INMMD 191_ ILTTP 196_ SMAKP 201_ RQDYS 206_ RTPGQ 211_ VLSLI 216_ SSLGF 221_ NTPIA 226_ EKNQD 231_ PANIL 236_ SACLS 241_ ETSQL 246_ SQGLV 251_ CPMSV 256_ DQKDT 261_ TPYSS 266_ KLLKS 271_ CLETV 276_ ASNPG 281_ MPVKC 286_ LTSNL 291_ LQSRK 296_ RLATS 301_ SASSQ 306_ SHTFI 311_ SSVES 316_ ECHSS 321_ PKWEK 326_ DCQES 331_ DEALG 336_ PTMMS 341_ WNAVE 346_ KLCAK 351_ SANAI 356_ ETKGF 361_ NKKDL 366_ ELALS 371_ PIHNS 376_ SALPT 381_ TGRSC 386_ VNLAK 391_ KCFSG 396_ EVSWE 401_ AVELD 406_ VNNIN 411_ MDTDT 416_ SQLGF 421_ HQSNQ 426_ WAVDS 431_ GGISE 436_ EHLGK 441_ RSLKR 446_ NFELV 451_ DSSPC 456_ KKIIQ 461_ NKKTC 466_ VEYKH 471_ NEMTN 476_ CYTNQ 481_ NTGLT 486_ VEVQD 491_ LKLSV 496_ HKSQQ 501_ NDCAN 506_ KENIV 511_ NSFTD 516_ KQQTP 521_ EKLPI 526_ PMIAK 531_ NLMCE 536_ LDEDC 541_ EKNSK 546_ RDYLS 551_ SSFLC 556_ SDDDR 561_ ASKNI 566_ SMNSD 571_ SSFPG 576_ ISIME 581_ SPLES 586_ QPLDS 591_ DRSIK 596_ ESSFE 601_ ESNIE 606_ DPLIV 611_ TPDCQ 616_ EKTSP 621_ KGVEN 626_ PAVQE 631_ SNQKM 636_ LGPPL 641_ EVLKT 646_ LASKR 651_ NAVAF 656_ RSFNS 661_ HINAS 666_ NNSEP 671_ SRMNM 676_ TSLDA 681_ MDISC 686_ AYSGS 691_ YPMAI 696_ TPTQK 701_ RRSCM 706_ PHQQT 711_ PNQIK 716_ SGTPY 721_ RTPKS 726_ VRRGV 731_ APVDD 736_ GRILG 741_ TPDYL 746_ APELL 751_ LGRAH 756_ GPAVD 761_ WWALG 766_ VCLFE 771_ FLTGI 776_ PPFND 781_ ETPQQ 786_ VFQNI 791_ LKRDI 796_ PWPEG 801_ EEKLS 806_ DNAQS 811_ AVEIL 816_ LTIDD 821_ TKRAG 826_ MKELK 831_ RHPLF 836_ SDVDW 841_ ENLQH 846_ QTMPF 851_ IPQPD 856_ DETDT 861_ SYFEA 866_ RNTAQ 871_HLTVS
1: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation