Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein) (hAPIP)
1_MSGCD 6_ AREGD 11_ CCSRR 16_ CGAQD 21_ KEHPR 26_ YLIPE 31_ LCKQF 36_ YHLGW 41_ VTGTG 46_ GGISL 51_ KHGDE 56_ IYIAP 61_ SGVQK 66_ ERIQP 71_ EDMFV 76_ CDINE 81_ KDISG 86_ PSPSK 91_ KLKKS 96_ QCTPL 101_ FMNAY 106_ TMRGA 111_ GAVIH 116_ THSKA 121_ AVMAT 126_ LLFPG 131_ REFKI 136_ THQEM 141_ IKGIK 146_ KCTSG 151_ GYYRY 156_ DDMLV 161_ VPIIE 166_ NTPEE 171_ KDLKD 176_ RMAHA 181_ MNEYP 186_ DSCAV 191_ LVRRH 196_ GVYVW 201_ GETWE 206_ KAKTM 211_ CECYD 216_ YLFDI 221_ AVSMK 226_ KVGLD 231_ PSQLP 236_VGENG
1: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death