Vacuolar-sorting protein SNF8 (ELL-associated protein of 30 kDa) (ESCRT-II complex subunit VPS22) (hVps22)
1_MHRRG 6_ VGAGA 11_ IAKKK 16_ LAEAK 21_ YKERG 26_ TVLAE 31_ DQLAQ 36_ MSKQL 41_ DMFKT 46_ NLEEF 51_ ASKHK 56_ QEIRK 61_ NPEFR 66_ VQFQD 71_ MCATI 76_ GVDPL 81_ ASGKG 86_ FWSEM 91_ LGVGD 96_ FYYEL 101_ GVQII 106_ EVCLA 111_ LKHRN 116_ GGLIT 121_ LEELH 126_ QQVLK 131_ GRGKF 136_ AQDVS 141_ QDDLI 146_ RAIKK 151_ LKALG 156_ TGFGI 161_ IPVGG 166_ TYLIQ 171_ SVPAE 176_ LNMDH 181_ TVVLQ 186_ LAEKN 191_ GYVTV 196_ SEIKA 201_ SLKWE 206_ TERAR 211_ QVLEH 216_ LLKEG 221_ LAWLD 226_ LQAPG 231_ EAHYW 236_ LPALF 241_ TDLYS 246_ QEITA 251_EEARE
1: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs, and plays a role in autophagy (PubMed:38423010). The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413)