Centromere protein N (CENP-N) (Interphase centromere complex protein 32)
1_MDETV 6_ AEFIK 11_ RTILK 16_ IPMNE 21_ LTTIL 26_ KAWDF 31_ LSENQ 36_ LQTVN 41_ FRQRK 46_ ESVVQ 51_ HLIHL 56_ CEEKR 61_ ASISD 66_ AALLD 71_ IIYMQ 76_ FHQHQ 81_ KVWEV 86_ FQMSK 91_ GPGED 96_ VDLFD 101_ MKQFK 106_ NSFKK 111_ ILQRA 116_ LKNVT 121_ VSFRE 126_ TEENA 131_ VWIRI 136_ AWGTQ 141_ YTKPN 146_ QYKPT 151_ YVVYY 156_ SQTPY 161_ AFTSS 166_ SMLRR 171_ NTPLL 176_ GQALT 181_ IASKH 186_ HQIVK 191_ MDLRS 196_ RYLDS 201_ LKAIV 206_ FKQYN 211_ QTFET 216_ HNSTT 221_ PLQER 226_ SLGLD 231_ INMDS 236_ RIIHE 241_ NIVEK 246_ ERVQR 251_ ITQET 256_ FGDYP 261_ QPQLE 266_ FAQYK 271_ LETKF 276_ KSGLN 281_ GSILA 286_ EREEP 291_ LRCLI 296_ KFSSP 301_ HLLEA 306_ LKSLA 311_ PAGIA 316_ DAPLS 321_ PLLTC 326_ IPNKR 331_MNYFK
1: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate