Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)
1_MSLER 6_ ELRQL 11_ SKAKA 16_ KAQRA 21_ GQRRE 26_ EAALC 31_ HQLGE 36_ LLAGH 41_ GRYAE 46_ ALEQH 51_ WQELQ 56_ LRERA 61_ DDPLG 66_ CAVAH 71_ RKIGE 76_ RLAEM 81_ EDYPA 86_ ALQHQ 91_ HQYLE 96_ LAHSL 101_ RNHTE 106_ LQRAW 111_ ATIGR 116_ THLDI 121_ YDHCQ 126_ SRDAL 131_ LQAQA 136_ AFEKS 141_ LAIVD 146_ EELEG 151_ TLAQG 156_ ELNEM 161_ RTRLY 166_ LNLGL 171_ TFESL 176_ QQTAL 181_ CNDYF 186_ RKSIF 191_ LAEQN 196_ HLYED 201_ LFRAR 206_ YNLGT 211_ IHWRA 216_ GQHSQ 221_ AMRCL 226_ EGARE 231_ CAHTM 236_ RKRFM 241_ ESECC 246_ VVIAQ 251_ VLQDL 256_ GDFLA 261_ AKRAL 266_ KKAYR 271_ LGSQK 276_ PVQRA 281_ AICQN 286_ LQHVL 291_ AVVRL 296_ QQQLE 301_ EAEGR 306_ DPQGA 311_ MVICE 316_ QLGDL 321_ FSKAG 326_ DFPRA 331_ AEAYQ 336_ KQLRF 341_ AELLD 346_ RPGAE 351_ RAIIH 356_ VSLAT 361_ TLGDM 366_ KDHHG 371_ AVRHY 376_ EEELR 381_ LRSGN 386_ VLEEA 391_ KTWLN 396_ IALSR 401_ EEAGD 406_ AYELL 411_ APCFQ 416_ KALSC 421_ AQQAQ 426_ RPQLQ 431_ RQVLQ 436_ HLHTV 441_ QLRLQ 446_ PQEAP 451_ ETETR 456_ LRELS 461_ VAEDE 466_ DEEEE 471_ AEEAA 476_ ATAES 481_ EALEA 486_ GEVEL 491_ SEGED 496_ DTDGL 501_ TPQLE 506_ EDEEL 511_ QGHLG 516_ RRKGS 521_ KWNRR 526_ NDMGE 531_ TLLHR 536_ ACIEG 541_ QLRRV 546_ QDLVR 551_ QGHPL 556_ NPRDY 561_ CGWTP 566_ LHEAC 571_ NYGHL 576_ EIVRF 581_ LLDHG 586_ AAVDD 591_ PGGQG 596_ CEGIT 601_ PLHDA 606_ LNCGH 611_ FEVAE 616_ LLLER 621_ GASVT 626_ LRTRK 631_ GLSPL 636_ ETLQQ 641_ WVKLY 646_ RRDLD 651_ LETRQ 656_ KARAM 661_ EMLLQ 666_ AAASG 671_ QDPHS 676_ SQAFH 681_ TPSSL 686_ LFDPE 691_ TSPPL 696_ SPCPE 701_ PPSNS 706_ TRLPE 711_ ASQAH 716_ VRVSP 721_ GQAAP 726_ AMARP 731_ RRSRH 736_ GPASS 741_ SSSSE 746_ GEDSA 751_ GPARP 756_ SQKRP 761_ RCSAT 766_ AQRVA 771_ AWTPG 776_ PASNR 781_ EAATA 786_ STSRA 791_ AYQAA 796_ IRGVG 801_ SAQSR 806_ LGPGP 811_ PRGHS 816_ KALAP 821_ QAALI 826_ PEEEC 831_ LAGDW 836_ LELDM 841_ PLTRS 846_ RRPRP 851_ RGTGD 856_ NRRPS 861_ STSGS 866_ DSEES 871_ RPRAR 876_ AKQVR 881_ LTCMQ 886_ SCSAP 891_ VNAGP 896_ SSLAS 901_ EPPGS 906_ PSTPR 911_ VSEPS 916_ GDSSA 921_ AGQPL 926_ GPAPP 931_ PPIRV 936_ RVQVQ 941_ DHLFL 946_ IPVPH 951_ SSDTH 956_ SVAWL 961_ AEQAA 966_ QRYYQ 971_ TCGLL 976_ PRLTL 981_ RKEGA 986_ LLAPQ 991_ DLIPD 996_ VLQSN 1001_ DEVLA 1006_ EVTSW 1011_ DLPPL 1016_ TDRYR 1021_ RACQS 1026_ LGQGE 1031_ HQQVL 1036_ QAVEL 1041_ QGLGL 1046_ SFSAC 1051_ SLALD 1056_ QAQLT 1061_ PLLRA 1066_ LKLHT 1071_ ALREL 1076_ RLAGN 1081_ RLGDK 1086_ CVAEL 1091_ VAALG 1096_ TMPSL 1101_ ALLDL 1106_ SSNHL 1111_ GPEGL 1116_ RQLAM 1121_ GLPGQ 1126_ ATLQS 1131_ LEELD 1136_ LSMNP 1141_ LGDGC 1146_ GQSLA 1151_ SLLHA 1156_ CPLLS 1161_ TLRLQ 1166_ ACGFG 1171_ PSFFL 1176_ SHQTA 1181_ LGSAF 1186_ QDAEH 1191_ LKTLS 1196_ LSYNA 1201_ LGAPA 1206_ LARTL 1211_ QSLPA 1216_ GTLLH 1221_ LELSS 1226_ VAAGK 1231_ GDSDL 1236_ MEPVF 1241_ RYLAK 1246_ EGCAL 1251_ AHLTL 1256_ SANHL 1261_ GDKAV 1266_ RDLCR 1271_ CLSLC 1276_ PSLIS 1281_ LDLSA 1286_ NPEIS 1291_ CASLE 1296_ ELLST 1301_ LQKRP 1306_ QGLSF 1311_ LGLSG 1316_ CAVQG 1321_ PLGLG 1326_ LWDKI 1331_ AAQLR 1336_ ELQLC 1341_ SRRLC 1346_ AEDRD 1351_ ALRQL 1356_ QPSRP 1361_ GPGEC 1366_ TLDHG 1371_SKLFF
1: Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:21113133, PubMed:26527279, PubMed:27338793, PubMed:27797818, PubMed:29478807, PubMed:30773278). The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication (PubMed:21055983, PubMed:21055984, PubMed:21055985). It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:27797818, PubMed:29478807). Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination (PubMed:27797818, PubMed:29478807). Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones (PubMed:27338793, PubMed:29478807). Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1 (PubMed:27338793)