ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein) (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha)
1_MGRGW 6_ GFLFG 11_ LLGAV 16_ WLLSS 21_ GHGEE 26_ QPPET 31_ AAQRC 36_ FCQVS 41_ GYLDD 46_ CTCDV 51_ ETIDR 56_ FNNYR 61_ LFPRL 66_ QKLLE 71_ SDYFR 76_ YYKVN 81_ LKRPC 86_ PFWND 91_ ISQCG 96_ RRDCA 101_ VKPCQ 106_ SDEVP 111_ DGIKS 116_ ASYKY 121_ SEEAN 126_ NLIEE 131_ CEQAE 136_ RLGAV 141_ DESLS 146_ EETQK 151_ AVLQW 156_ TKHDD 161_ SSDNF 166_ CEADD 171_ IQSPE 176_ AEYVD 181_ LLLNP 186_ ERYTG 191_ YKGPD 196_ AWKIW 201_ NVIYE 206_ ENCFK 211_ PQTIK 216_ RPLNP 221_ LASGQ 226_ GTSEE 231_ NTFYS 236_ WLEGL 241_ CVEKR 246_ AFYRL 251_ ISGLH 256_ ASINV 261_ HLSAR 266_ YLLQE 271_ TWLEK 276_ KWGHN 281_ ITEFQ 286_ QRFDG 291_ ILTEG 296_ EGPRR 301_ LKNLY 306_ FLYLI 311_ ELRAL 316_ SKVLP 321_ FFERP 326_ DFQLF 331_ TGNKI 336_ QDEEN 341_ KMLLL 346_ EILHE 351_ IKSFP 356_ LHFDE 361_ NSFFA 366_ GDKKE 371_ AHKLK 376_ EDFRL 381_ HFRNI 386_ SRIMD 391_ CVGCF 396_ KCRLW 401_ GKLQT 406_ QGLGT 411_ ALKIL 416_ FSEKL 421_ IANMP 426_ ESGPS 431_ YEFHL 436_ TRQEI 441_ VSLFN 446_ AFGRI 451_ STSVK 456_ ELENF 461_RNLLQ
1: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins (PubMed:29858230). Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin