Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5)
1_MAFRQ 6_ ALQLA 11_ ACGLA 16_ GGSAA 21_ VLFSA 26_ VAVGK 31_ PRAGG 36_ DAEPR 41_ PAEPP 46_ AWAGG 51_ ARPGP 56_ GVWDP 61_ NWDRR 66_ EPLSL 71_ INVRK 76_ RNVES 81_ GEEEL 86_ ASKLD 91_ HYKAK 96_ ATRHI 101_ FLIRH 106_ SQYHV 111_ DGSLE 116_ KDRTL 121_ TPLGR 126_ EQAEL 131_ TGLRL 136_ ASLGL 141_ KFNKI 146_ VHSSM 151_ TRAIE 156_ TTDII 161_ SRHLP 166_ GVCKV 171_ STDLL 176_ REGAP 181_ IEPDP 186_ PVSHW 191_ KPEAV 196_ QYYED 201_ GARIE 206_ AAFRN 211_ YIHRA 216_ DARQE 221_ EDSYE 226_ IFICH 231_ ANVIR 236_ YIVCR 241_ ALQFP 246_ PEGWL 251_ RLSLN 256_ NGSIT 261_ HLVIR 266_ PNGRV 271_ ALRTL 276_ GDTGF 281_MPPDK
1: Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy (PubMed:24746696, PubMed:32439975). Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1 (PubMed:32439975). Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation (PubMed:37498743). Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3 (PubMed:24746696). Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 (PubMed:18387606). Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria (PubMed:22265414)