Integrator complex subunit 4 (Int4)
1_MAAHL 6_ KKRVY 11_ EEFTK 16_ VVQPQ 21_ EEIAT 26_ KKLRL 31_ TKPSK 36_ SAALH 41_ IDLCK 46_ ATSPA 51_ DALQY 56_ LLQFA 61_ RKPVE 66_ AESVE 71_ GVVRI 76_ LLEHY 81_ YKEND 86_ PSVRL 91_ KIASL 96_ LGLLS 101_ KTAGF 106_ SPDCI 111_ MDDAI 116_ NILQN 121_ EKSHQ 126_ VLAQL 131_ LDTLL 136_ AIGTK 141_ LPENQ 146_ AIQMR 151_ LVDVA 156_ CKHLT 161_ DTSHG 166_ VRNKC 171_ LQLLG 176_ NLGSL 181_ EKSVT 186_ KDAEG 191_ LAARD 196_ VQKII 201_ GDYFS 206_ DQDPR 211_ VRTAA 216_ IKAML 221_ QLHER 226_ GLKLH 231_ QTIYN 236_ QACKL 241_ LSDDY 246_ EQVRS 251_ AAVQL 256_ IWVVS 261_ QLYPE 266_ SIVPI 271_ PSSNE 276_ EIRLV 281_ DDAFG 286_ KICHM 291_ VSDGS 296_ WVVRV 301_ QAAKL 306_ LGSME 311_ QVSSH 316_ FLEQT 321_ LDKKL 326_ MSDLR 331_ RKRTA 336_ HERAK 341_ ELYSS 346_ GEFSS 351_ GRKWG 356_ DDAPK 361_ EEVDT 366_ GAVNL 371_ IESGA 376_ CGAFV 381_ HGLED 386_ EMYEV 391_ RIAAV 396_ EALCM 401_ LAQSS 406_ PSFAE 411_ KCLDF 416_ LVDMF 421_ NDEIE 426_ EVRLQ 431_ SIHTM 436_ RKISN 441_ NITLR 446_ EDQLD 451_ TVLAV 456_ LEDSS 461_ RDIRE 466_ ALHEL 471_ LCCTN 476_ VSTKE 481_ GIHLA 486_ LVELL 491_ KNLTK 496_ YPTDR 501_ DSIWK 506_ CLKFL 511_ GSRHP 516_ TLVLP 521_ LVPEL 526_ LSTHP 531_ FFDTA 536_ EPDMD 541_ DPAYI 546_ AVLVL 551_ IFNAA 556_ KTCPT 561_ MPALF 566_ SDHTF 571_ RHYAY 576_ LRDSL 581_ SHLVP 586_ ALRLP 591_ GRKLV 596_ SSAVS 601_ PSIIP 606_ QEDPS 611_ QQFLQ 616_ QSLER 621_ VYSLQ 626_ HLDPQ 631_ GAQEL 636_ LEFTI 641_ RDLQR 646_ LGELQ 651_ SELAG 656_ VADFS 661_ ATYLR 666_ CQLLL 671_ IKALQ 676_ EKLWN 681_ VAAPL 686_ YLKQS 691_ DLASA 696_ AAKQI 701_ MEETY 706_ KMEFM 711_ YSGVE 716_ NKQVV 721_ IIHHM 726_ RLQAK 731_ ALQLI 736_ VTART 741_ TRGLD 746_ PLFGM 751_ CEKFL 756_ QEVDF 761_ FQRYF 766_ IADLP 771_ HLQDS 776_ FVDKL 781_ LDLMP 786_ RLMTS 791_ KPAEV 796_ VKILQ 801_ TMLRQ 806_ SAFLH 811_ LPLPE 816_ QIHKA 821_ SATII 826_ EPAGE 831_ SDNPL 836_ RFTSG 841_ LVVAL 846_ DVDAT 851_ LEHVQ 856_ DPQNT 861_ VKVQV 866_ LYPDG 871_ QAQMI 876_ HPKPA 881_ DFRNP 886_ GPGRH 891_ RLITQ 896_ VYLSH 901_ TAWTE 906_ ACQVE 911_ VRLLL 916_ AYNSS 921_ ARIPK 926_ CPWME 931_ GGEMS 936_ PQVET 941_ SIEGT 946_ IPFSK 951_ PVKVY 956_IMPKP
1: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:29471365, PubMed:33243860, PubMed:33548203, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS4 acts as an scaffold that links INTS9 and INTS11 (PubMed:29471365, PubMed:33548203). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267)