2-oxoadipate dehydrogenase complex component E1 (E1a) (OADC-E1) (OADH-E1) (EC 1.2.4.-) (2-oxoadipate dehydrogenase, mitochondrial) (Alpha-ketoadipate dehydrogenase) (Alpha-KADH-E1) (Dehydrogenase E1 and transketolase domain-containing protein 1) (Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial)
1_MASAT 6_ AAAAR 11_ RGLGR 16_ ALPLF 21_ WRGYQ 26_ TERGV 31_ YGYRP 36_ RKPES 41_ REPQG 46_ ALERP 51_ PVDHG 56_ LARLV 61_ TVYCE 66_ HGHKA 71_ AKINP 76_ LFTGQ 81_ ALLEN 86_ VPEIQ 91_ ALVQT 96_ LQGPF 101_ HTAGL 106_ LNMGK 111_ EEASL 116_ EEVLV 121_ YLNQI 126_ YCGQI 131_ SIETS 136_ QLQSQ 141_ DEKDW 146_ FAKRF 151_ EELQK 156_ ETFTT 161_ EERKH 166_ LSKLM 171_ LESQE 176_ FDHFL 181_ ATKFS 186_ TVKRY 191_ GGEGA 196_ ESMMG 201_ FFHEL 206_ LKMSA 211_ YSGIT 216_ DVIIG 221_ MPHRG 226_ RLNLL 231_ TGLLQ 236_ FPPEL 241_ MFRKM 246_ RGLSE 251_ FPENF 256_ SATGD 261_ VLSHL 266_ TSSVD 271_ LYFGA 276_ HHPLH 281_ VTMLP 286_ NPSHL 291_ EAVNP 296_ VAVGK 301_ TRGRQ 306_ QSRQD 311_ GDYSP 316_ DNSAQ 321_ PGDRV 326_ ICLQV 331_ HGDAS 336_ FCGQG 341_ IVPET 346_ FTLSN 351_ LPHFR 356_ IGGSV 361_ HLIVN 366_ NQLGY 371_ TTPAE 376_ RGRSS 381_ LYCSD 386_ IGKLV 391_ GCAII 396_ HVNGD 401_ SPEEV 406_ VRATR 411_ LAFEY 416_ QRQFR 421_ KDVII 426_ DLLCY 431_ RQWGH 436_ NELDE 441_ PFYTN 446_ PIMYK 451_ IIRAR 456_ KSIPD 461_ TYAEH 466_ LIAGG 471_ LMTQE 476_ EVSEI 481_ KSSYY 486_ AKLND 491_ HLNNM 496_ AHYRP 501_ PALNL 506_ QAHWQ 511_ GLAQP 516_ EAQIT 521_ TWSTG 526_ VPLDL 531_ LRFVG 536_ MKSVE 541_ VPREL 546_ QMHSH 551_ LLKTH 556_ VQSRM 561_ EKMMD 566_ GIKLD 571_ WATAE 576_ ALALG 581_ SLLAQ 586_ GFNVR 591_ LSGQD 596_ VGRGT 601_ FSQRH 606_ AIVVC 611_ QETDD 616_ TYIPL 621_ NHMDP 626_ NQKGF 631_ LEVSN 636_ SPLSE 641_ EAVLG 646_ FEYGM 651_ SIESP 656_ KLLPL 661_ WEAQF 666_ GDFFN 671_ GAQII 676_ FDTFI 681_ SGGEA 686_ KWLLQ 691_ SGIVI 696_ LLPHG 701_ YDGAG 706_ PDHSS 711_ CRIER 716_ FLQMC 721_ DSAEE 726_ GVDGD 731_ TVNMF 736_ VVHPT 741_ TPAQY 746_ FHLLR 751_ RQMVR 756_ NFRKP 761_ LIVAS 766_ PKMLL 771_ RLPAA 776_ VSTLQ 781_ EMAPG 786_ TTFNP 791_ VIGDS 796_ SVDPK 801_ KVKTL 806_ VFCSG 811_ KHFYS 816_ LVKQR 821_ ESLGA 826_ KKHDF 831_ AIIRV 836_ EELCP 841_ FPLDS 846_ LQQEM 851_ SKYKH 856_ VKDHI 861_ WSQEE 866_ PQNMG 871_ PWSFV 876_ SPRFE 881_ KQLAC 886_ KLRLV 891_ GRPPL 896_ PVPAV 901_ GIGTV 906_ HLHQH 911_EDILA
1: 2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC) (PubMed:29191460, PubMed:29752936, PubMed:32303640, PubMed:32633484, PubMed:32695416). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC (PubMed:29191460, PubMed:32695416). Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (Probable) (PubMed:29752936, PubMed:32303640, PubMed:32633484). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate (PubMed:29191460, PubMed:29752936, PubMed:32633484, PubMed:32695416). Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate (Probable)