Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6)
1_MAPPA 6_ APGRD 11_ RVGRE 16_ DEDGW 21_ ETRGD 26_ RKARK 31_ PLVEK 36_ KRRAR 41_ INESL 46_ QELRL 51_ LLAGA 56_ EVQAK 61_ LENAE 66_ VLELT 71_ VRRVQ 76_ GVLRG 81_ RARER 86_ EQLQA 91_ EASER 96_ FAAGY 101_ IQCMH 106_ EVHTF 111_ VSTCQ 116_ AIDAT 121_ VAAEL 126_ LNHLL 131_ ESMPL 136_ REGSS 141_ FQDLL 146_ GDALA 151_ GPPRA 156_ PGRSG 161_ WPAGG 166_ APGSP 171_ IPSPP 176_ GPGDD 181_ LCSDL 186_ EEAPE 191_ AELSQ 196_ APAEG 201_ PDLVP 206_ AALGS 211_ LTTAQ 216_IARSV
1: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity)