Protein ABHD8 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 8) (Abhydrolase domain-containing protein 8)
1_MLTGV 6_ TDGIF 11_ CCLLG 16_ TPPNA 21_ VGPLE 26_ SVESS 31_ DGYTF 36_ VEVKP 41_ GRVLR 46_ VKHAG 51_ PAPAA 56_ APPPP 61_ SSASS 66_ DAAQG 71_ DLSGL 76_ VRCQR 81_ RITVY 86_ RNGRL 91_ LVENL 96_ GRAPR 101_ ADLLH 106_ GQNGS 111_ GEPPA 116_ ALEVE 121_ LADPA 126_ GSDGR 131_ LAPGS 136_ AGSGS 141_ GSGSG 146_ GRRRR 151_ ARRPK 156_ RTIHI 161_ DCEKR 166_ ITSCK 171_ GAQAD 176_ VVLFF 181_ IHGVG 186_ GSLAI 191_ WKEQL 196_ DFFVR 201_ LGYEV 206_ VAPDL 211_ AGHGA 216_ SSAPQ 221_ VAAAY 226_ TFYAL 231_ AEDMR 236_ AIFKR 241_ YAKKR 246_ NVLIG 251_ HSYGV 256_ SFCTF 261_ LAHEY 266_ PDLVH 271_ KVIMI 276_ NGGGP 281_ TALEP 286_ SFCSI 291_ FNMPT 296_ CVLHC 301_ LSPCL 306_ AWSFL 311_ KAGFA 316_ RQGAK 321_ EKQLL 326_ KEGNA 331_ FNVSS 336_ FVLRA 341_ MMSGQ 346_ YWPEG 351_ DEVYH 356_ AELTV 361_ PVLLV 366_ HGMHD 371_ KFVPV 376_ EEDQR 381_ MAEIL 386_ LLAFL 391_ KLIDE 396_ GSHMV 401_ MLECP 406_ ETVNT 411_ LLHEF 416_ LLWEP 421_ EPSPK 426_ ALPEP 431_LPAPP
1: Negatively regulates NLRP3-driven inflammation (PubMed:39225180). Promotes NLRP3 degradation through the chaperone-mediated autophagy (CMA) pathway, hence attenuating inflammasome activation and IL1B secretion. Acts by recruiting palmitoyltransferase ZDHHC12 to NLRP3, facilitating NLRP3 palmitoylation and subsequent degradation (PubMed:39225180)