G patch domain-containing protein 3
1_MAVPG 6_ EAEEE 11_ ATVYL 16_ VVSGI 21_ PSVLR 26_ SAHLR 31_ SYFSQ 36_ FREER 41_ GGGFL 46_ CFHYR 51_ HRPER 56_ APPQA 61_ APNSA 66_ LIPTD 71_ PAAEG 76_ QLLSQ 81_ TSATD 86_ VRPLS 91_ TRDST 96_ PIQTR 101_ TCCCV 106_ ISVRG 111_ LAQAQ 116_ RLIRM 121_ YSGRR 126_ WLDSH 131_ GTWLP 136_ GRCLI 141_ RRLRL 146_ PTEAS 151_ GLGSF 156_ PFKTR 161_ KELQS 166_ WKAEN 171_ EAFTL 176_ ADLKQ 181_ LPELN 186_ PPVLM 191_ PRGNV 196_ GTPLR 201_ VFLEL 206_ IRACR 211_ LPPRI 216_ ITQLQ 221_ LQFPK 226_ TGSSR 231_ RYGNV 236_ PFEYE 241_ DSETV 246_ EQEEL 251_ VYTAE 256_ GEEIP 261_ QGTYL 266_ ADIPA 271_ SPCGE 276_ PEEEV 281_ GKEEE 286_ EESHS 291_ DEDDD 296_ RGEEW 301_ ERHEA 306_ LHEDV 311_ TGQER 316_ TTEQL 321_ FEEEI 326_ ELKWE 331_ KGGSG 336_ LVFYT 341_ DAQFW 346_ QEEEG 351_ DFDEQ 356_ TADDW 361_ DVDMS 366_ VYYDR 371_ DGGDK 376_ DARDS 381_ VQMRL 386_ EQRLR 391_ DGQED 396_ GSVIE 401_ RQVGT 406_ FERHT 411_ KGIGR 416_ KVMER 421_ QGWAE 426_ GQGLG 431_ CRCSG 436_ VPEAL 441_ DSDGQ 446_ HPRCK 451_ RGLGY 456_ HGEKL 461_ QPFGQ 466_ LKRPR 471_ RNGLG 476_ LISTI 481_ YDEPL 486_ PQDQT 491_ ESLLR 496_ RQPPT 501_ SMKFR 506_ TDMAF 511_ VRGSS 516_CASDS
1: Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development (PubMed:28397860). Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768)