LIM domain-containing protein ajuba
1_MERLG 6_ EKASR 11_ LLEKF 16_ GRRKG 21_ ESSRS 26_ GSDGT 31_ PGPGK 36_ GRLSG 41_ LGGPR 46_ KSGPR 51_ GATGG 56_ PGDEP 61_ LEPAR 66_ EQGSL 71_ DAERN 76_ QRGSF 81_ EAPRY 86_ EGSFP 91_ AGPPP 96_ TRALP 101_ LPQSL 106_ PPDFR 111_ LEPTA 116_ PALSP 121_ RSSFA 126_ SSSAS 131_ DASKP 136_ SSPRG 141_ SLLLD 146_ GAGAG 151_ GAGGS 156_ RPCSN 161_ RTSGI 166_ SMGYD 171_ QRHGS 176_ PLPAG 181_ PCLFG 186_ PPLAG 191_ APAGY 196_ SPGGV 201_ PSAYP 206_ ELHAA 211_ LDRLY 216_ AQRPA 221_ GFGCQ 226_ ESRHS 231_ YPPAL 236_ GSPGA 241_ LAGAG 246_ VGAAG 251_ PLERR 256_ GAQPG 261_ RHSVT 266_ GYGDC 271_ AVGAR 276_ YQDEL 281_ TALLR 286_ LTVGT 291_ GGREA 296_ GARGE 301_ PSGIE 306_ PSGLE 311_ EPPGP 316_ FVPEA 321_ ARARM 326_ REPEA 331_ REDYF 336_ GTCIK 341_ CNKGI 346_ YGQSN 351_ ACQAL 356_ DSLYH 361_ TQCFV 366_ CCSCG 371_ RTLRC 376_ KAFYS 381_ VNGSV 386_ YCEED 391_ YLFSG 396_ FQEAA 401_ EKCCV 406_ CGHLI 411_ LEKIL 416_ QAMGK 421_ SYHPG 426_ CFRCI 431_ VCNKC 436_ LDGIP 441_ FTVDF 446_ SNQVY 451_ CVTDY 456_ HKNYA 461_ PKCAA 466_ CGQPI 471_ LPSEG 476_ CEDIV 481_ RVISM 486_ DRDYH 491_ FECYH 496_ CEDCR 501_ MQLSD 506_ EEGCC 511_ CFPLD 516_ GHLLC 521_ HGCHM 526_ QRLNA 531_RQPPA
1: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1