Mannose-1-phosphate guanyltransferase alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha)
1_MLKAV 6_ ILIGG 11_ PQKGT 16_ RFRPL 21_ SFEVP 26_ KPLFP 31_ VAGVP 36_ MIQHH 41_ IEACA 46_ QVPGM 51_ QEILL 56_ IGFYQ 61_ PDEPL 66_ TQFLE 71_ AAQQE 76_ FNLPV 81_ RYLQE 86_ FAPLG 91_ TGGGL 96_ YHFRD 101_ QILAG 106_ SPEAF 111_ FVLNA 116_ DVCSD 121_ FPLSA 126_ MLEAH 131_ RRQRH 136_ PFLLL 141_ GTTAN 146_ RTQSL 151_ NYGCI 156_ VENPQ 161_ THEVL 166_ HYVEK 171_ PSTFI 176_ SDIIN 181_ CGIYL 186_ FSPEA 191_ LKPLR 196_ DVFQR 201_ NQQDG 206_ QLEDS 211_ PGLWP 216_ GAGTI 221_ RLEQD 226_ VFSAL 231_ AGQGQ 236_ IYVHL 241_ TDGIW 246_ SQIKS 251_ AGSAL 256_ YASRL 261_ YLSRY 266_ QDTHP 271_ ERLAK 276_ HTPGG 281_ PWIRG 286_ NVYIH 291_ PTAKV 296_ APSAV 301_ LGPNV 306_ SIGKG 311_ VTVGE 316_ GVRLR 321_ ESIVL 326_ HGATL 331_ QEHTC 336_ VLHSI 341_ VGWGS 346_ TVGRW 351_ ARVEG 356_ TPSDP 361_ NPNDP 366_ RARMD 371_ SESLF 376_ KDGKL 381_ LPAIT 386_ ILGCR 391_ VRIPA 396_ EVLIL 401_ NSIVL 406_ PHKEL 411_SRSFT
1: Regulatory subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex; reduces the catalytic activity of GMPPB when part of the complex (PubMed:24035193, PubMed:33986552). Mediates allosteric feedback inhibition of GMPPB catalytic activity upon binding GDP-alpha-D-mannose (PubMed:24035193, PubMed:33986552). Together with GMPPB regulates GDP-alpha-D-mannose levels (PubMed:33986552)