Putative protein-lysine deacylase ABHD14B (EC 2.3.1.-) (Alpha/beta hydrolase domain-containing protein 14B) (Abhydrolase domain-containing protein 14B) (CCG1-interacting factor B)
1_MAASV 6_ EQREG 11_ TIQVQ 16_ GQALF 21_ FREAL 26_ PGSGQ 31_ ARFSV 36_ LLLHG 41_ IRFSS 46_ ETWQN 51_ LGTLH 56_ RLAQA 61_ GYRAV 66_ AIDLP 71_ GLGHS 76_ KEAAA 81_ PAPIG 86_ ELAPG 91_ SFLAA 96_ VVDAL 101_ ELGPP 106_ VVISP 111_ SLSGM 116_ YSLPF 121_ LTAPG 126_ SQLPG 131_ FVPVA 136_ PICTD 141_ KINAA 146_ NYASV 151_ KTPAL 156_ IVYGD 161_ QDPMG 166_ QTSFE 171_ HLKQL 176_ PNHRV 181_ LIMKG 186_ AGHPC 191_ YLDKP 196_ EEWHT 201_GLLDF
1: Acts as an atypical protein-lysine deacetylase in vitro (PubMed:31478652). Catalyzes the deacetylation of lysine residues using CoA as substrate, generating acetyl-CoA and the free amine of protein-lysine residues (PubMed:31478652). Additional experiments are however required to confirm the protein-lysine deacetylase activity in vivo (Probable). Has hydrolase activity towards various surrogate p-nitrophenyl (pNp) substrates, such as pNp-butyrate, pNp-acetate and pNp-octanoate in vitro, with a strong preference for pNp-acetate (PubMed:14672934, PubMed:31478652). May activate transcription (PubMed:14672934)