PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4)
1_MATGG 6_ YRTSS 11_ GLGGS 16_ TTDFL 21_ EEWKA 26_ KREKM 31_ RAKQN 36_ PPGPA 41_ PPGGG 46_ SSDAA 51_ GKPPA 56_ GALGT 61_ PAAAA 66_ ANELN 71_ NNLPG 76_ GAPAA 81_ PAVPG 86_ PGGVN 91_ CAVGS 96_ AMLTR 101_ AAPGP 106_ RRSED 111_ EPPAA 116_ SASAA 121_ PPPQR 126_ DEEEP 131_ DGVPE 136_ KGKSS 141_ GPSAR 146_ KGKGQ 151_ IEKRK 156_ LREKR 161_ RSTGV 166_ VNIPA 171_ AECLD 176_ EYEDD 181_ EAGQK 186_ ERKRE 191_ DAITQ 196_ QNTIQ 201_ NEAVN 206_ LLDPG 211_ SSYLL 216_ QEPPR 221_ TVSGR 226_ YKSTT 231_ SVSEE 236_ DVSSR 241_ YSRTD 246_ RSGFP 251_ RYNRD 256_ ANVSG 261_ TLVSS 266_ STLEK 271_ KIEDL 276_ EKEVV 281_ RERQE 286_ NLRLV 291_ RLMQD 296_ KEEMI 301_ GKLKE 306_ EIDLL 311_ NRDLD 316_ DIEDE 321_ NEQLK 326_ QENKT 331_LLKVV
1: Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1