tRNA N(3)-methylcytidine methyltransferase METTL2A (EC 2.1.1.-) (Methyltransferase-like protein 2A)
1_MAGSY 6_ PEGAP 11_ AVLAD 16_ KRQQF 21_ GSRFL 26_ RDPAR 31_ VFHHN 36_ AWDNV 41_ EWSEE 46_ QAAAA 51_ ERKVQ 56_ ENSIQ 61_ RVCQE 66_ KQVDY 71_ EINAH 76_ KYWND 81_ FYKIH 86_ ENGFF 91_ KDRHW 96_ LFTEF 101_ PELAP 106_ SQNQN 111_ HLKDW 116_ FLENK 121_ SEVPE 126_ CRNNE 131_ DGPGL 136_ IMEEQ 141_ HKCSS 146_ KSLEH 151_ KTQTL 156_ PVEEN 161_ VTQKI 166_ SDLEI 171_ CADEF 176_ PGSSA 181_ TYRIL 186_ EVGCG 191_ VGNTV 196_ FPILQ 201_ TNNDP 206_ GLFVY 211_ CCDFS 216_ STAIE 221_ LVQTN 226_ SEYDP 231_ SRCFA 236_ FVHDL 241_ CDEEK 246_ SYPVP 251_ KGSLD 256_ IIILI 261_ FVLSA 266_ IVPDK 271_ MQKAI 276_ NRLSR 281_ LLKPG 286_ GMMLL 291_ RDYGR 296_ YDMAQ 301_ LRFKK 306_ GQCLS 311_ GNFYV 316_ RGDGT 321_ RVYFF 326_ TQEEL 331_ DTLFT 336_ TAGLE 341_ KVQNL 346_ VDRRL 351_ QVNRG 356_ KQLTM 361_ YRVWI 366_ QCKYC 371_KPLLS
1: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557). N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557)