THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45)
1_MAVPA 6_ AAMGP 11_ SALGQ 16_ SGPGS 21_ MAPWC 26_ SVSSG 31_ PSRYV 36_ LGMQE 41_ LFRGH 46_ SKTRE 51_ FLAHS 56_ AKVHS 61_ VAWSC 66_ DGRRL 71_ ASGSF 76_ DKTAS 81_ VFLLE 86_ KDRLV 91_ KENNY 96_ RGHGD 101_ SVDQL 106_ CWHPS 111_ NPDLF 116_ VTASG 121_ DKTIR 126_ IWDVR 131_ TTKCI 136_ ATVNT 141_ KGENI 146_ NICWS 151_ PDGQT 156_ IAVGN 161_ KDDVV 166_ TFIDA 171_ KTHRS 176_ KAEEQ 181_ FKFEV 186_ NEISW 191_ NNDNN 196_ MFFLT 201_ NGNGC 206_ INILS 211_ YPELK 216_ PVQSI 221_ NAHPS 226_ NCICI 231_ KFDPM 236_ GKYFA 241_ TGSAD 246_ ALVSL 251_ WDVDE 256_ LVCVR 261_ CFSRL 266_ DWPVR 271_ TLSFS 276_ HDGKM 281_ LASAS 286_ EDHFI 291_ DIAEV 296_ ETGDK 301_ LWEVQ 306_ CESPT 311_ FTVAW 316_ HPKRP 321_ LLAFA 326_ CDDKD 331_ GKYDS 336_ SREAG 341_ TVKLF 346_GLPND
1: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602)
2: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production