Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4)
1_MLASP 6_ ATETT 11_ VLMSQ 16_ TEADL 21_ ALRPP 26_ PPLGT 31_ AGQPR 36_ LGPPP 41_ RRARR 46_ FSGKA 51_ EPRPR 56_ SSRLS 61_ RRSSV 66_ DLGLL 71_ SSWSL 76_ PASPA 81_ PDPPD 86_ PPDSA 91_ GPGPA 96_ RSPPP 101_ SSKEP 106_ PEGTW 111_ TEGAP 116_ VKAAE 121_ DSARP 126_ ELPDS 131_ AVGPG 136_ SREPL 141_ RVPEA 146_ VALER 151_ RREQE 156_ EKEDM 161_ ETQAV 166_ ATSPD 171_ GRYLK 176_ FDIEI 181_ GRGSF 186_ KTVYR 191_ GLDTD 196_ TTVEV 201_ AWCEL 206_ QTRKL 211_ SRAER 216_ QRFSE 221_ EVEML 226_ KGLQH 231_ PNIVR 236_ FYDSW 241_ KSVLR 246_ GQVCI 251_ VLVTE 256_ LMTSG 261_ TLKTY 266_ LRRFR 271_ EMKPR 276_ VLQRW 281_ SRQIL 286_ RGLHF 291_ LHSRV 296_ PPILH 301_ RDLKC 306_ DNVFI 311_ TGPTG 316_ SVKIG 321_ DLGLA 326_ TLKRA 331_ SFAKS 336_ VIGTP 341_ EFMAP 346_ EMYEE 351_ KYDEA 356_ VDVYA 361_ FGMCM 366_ LEMAT 371_ SEYPY 376_ SECQN 381_ AAQIY 386_ RKVTS 391_ GRKPN 396_ SFHKV 401_ KIPEV 406_ KEIIE 411_ GCIRT 416_ DKNER 421_ FTIQD 426_ LLAHA 431_ FFREE 436_ RGVHV 441_ ELAEE 446_ DDGEK 451_ PGLKL 456_ WLRME 461_ DARRG 466_ GRPRD 471_ NQAIE 476_ FLFQL 481_ GRDAA 486_ EEVAQ 491_ EMVAL 496_ GLVCE 501_ ADYQP 506_ VARAV 511_ RERVA 516_ AIQRK 521_ REKLR 526_ KAREL 531_ EALPP 536_ EPGPP 541_ PATVP 546_ MAPGP 551_ PSVFP 556_ PEPEE 561_ PEADQ 566_ HQPFL 571_ FRHAS 576_ YSSTT 581_ SDCET 586_ DGYLS 591_ SSGFL 596_ DASDP 601_ ALQPP 606_ GGVPS 611_ SLAES 616_ HLCLP 621_ SAFAL 626_ SIPRS 631_ GPGSD 636_ FSPGD 641_ SYASD 646_ AASGL 651_ SDVGE 656_ GMGQM 661_ RRPPG 666_ RNLRR 671_ RPRSR 676_ LRVTS 681_ VSDQN 686_ DRVVE 691_ CQLQT 696_ HNSKM 701_ VTFRF 706_ DLDGD 711_ SPEEI 716_ AAAMV 721_ YNEFI 726_ LPSER 731_ DGFLR 736_ RIREI 741_ IQRVE 746_ TLLKR 751_ DTGPM 756_ EAAED 761_ TLSPQ 766_ EEPAP 771_ LPALP 776_ VPLPD 781_ PSNEE 786_ LQSST 791_ SLEHR 796_ SWTAF 801_ STSSS 806_ SPGTP 811_ LSPGN 816_ PFSPG 821_ TPISP 826_ GPIFP 831_ ITSPP 836_ CHPSP 841_ SPFSP 846_ ISSQV 851_ SSNPS 856_ PHPTS 861_ SPLPF 866_ SSSTP 871_ EFPVP 876_ LSQCP 881_ WSSLP 886_ TTSPP 891_ TFSPT 896_ CSQVT 901_ LSSPF 906_ FPPCP 911_ STSSF 916_ PSTTA 921_ APLLS 926_ LASAF 931_ SLAVM 936_ TVAQS 941_ LLSPS 946_ PGLLS 951_ QSPPA 956_ PPSPL 961_ PSLPL 966_ PPPVA 971_ PGGQE 976_ SPSPH 981_ TAEVE 986_ SEASP 991_ PPARP 996_ LPGEA 1001_ RLAPI 1006_ SEEGK 1011_ PQLVG 1016_ RFQVT 1021_ SSKEP 1026_ AEPLP 1031_ LQPTS 1036_ PTLSG 1041_ SPKPS 1046_ TPQLT 1051_ SESSD 1056_ TEDSA 1061_ GGGPE 1066_ TREAL 1071_ AESDR 1076_ AAEGL 1081_ GAGVE 1086_ EEGDD 1091_ GKEPQ 1096_ VGGSP 1101_ QPLSH 1106_ PSPVW 1111_ MNYSY 1116_ SSLCL 1121_ SSEES 1126_ ESSGE 1131_ DEEFW 1136_ AELQS 1141_ LRQKH 1146_ LSEVE 1151_ TLQTL 1156_ QKKEI 1161_ EDLYS 1166_ RLGKQ 1171_ PPPGI 1176_ VAPAA 1181_ MLSSR 1186_ QRRLS 1191_ KGSFP 1196_ TSRRN 1201_ SLQRS 1206_ EPPGP 1211_ GIMRR 1216_ NSLSG 1221_ SSTGS 1226_ QEQRA 1231_ SKGVT 1236_FAGDV
1: Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693)