Piwi-like protein 1 (EC 3.1.26.-)
1_MTGRA 6_ RARAR 11_ GRARG 16_ QETAQ 21_ LVGST 26_ ASQQP 31_ GYIQP 36_ RPQPP 41_ PAEGE 46_ LFGRG 51_ RQRGT 56_ AGGTA 61_ KSQGL 66_ QISAG 71_ FQELS 76_ LAERG 81_ GRRRD 86_ FHDLG 91_ VNTRQ 96_ NLDHV 101_ KESKT 106_ GSSGI 111_ IVRLS 116_ TNHFR 121_ LTSRP 126_ QWALY 131_ QYHID 136_ YNPLM 141_ EARRL 146_ RSALL 151_ FQHED 156_ LIGKC 161_ HAFDG 166_ TILFL 171_ PKRLQ 176_ QKVTE 181_ VFSKT 186_ RNGED 191_ VRITI 196_ TLTNE 201_ LPPTS 206_ PTCLQ 211_ FYNII 216_ FRRLL 221_ KIMNL 226_ QQIGR 231_ NYYNP 236_ NDPID 241_ IPSHR 246_ LVIWP 251_ GFTTS 256_ ILQYE 261_ NSIML 266_ CTDVS 271_ HKVLR 276_ SETVL 281_ DFMFN 286_ FYHQT 291_ EEHKF 296_ QEQVS 301_ KELIG 306_ LVVLT 311_ KYNNK 316_ TYRVD 321_ DIDWD 326_ QNPKS 331_ TFKKA 336_ DGSEV 341_ SFLEY 346_ YRKQY 351_ NQEIT 356_ DLKQP 361_ VLVSQ 366_ PKRRR 371_ GPGGT 376_ LPGPA 381_ MLIPE 386_ LCYLT 391_ GLTDK 396_ MRNDF 401_ NVMKD 406_ LAVHT 411_ RLTPE 416_ QRQRE 421_ VGRLI 426_ DYIHK 431_ NDNVQ 436_ RELRD 441_ WGLSF 446_ DSNLL 451_ SFSGR 456_ ILQTE 461_ KIHQG 466_ GKTFD 471_ YNPQF 476_ ADWSK 481_ ETRGA 486_ PLISV 491_ KPLDN 496_ WLLIY 501_ TRRNY 506_ EAANS 511_ LIQNL 516_ FKVTP 521_ AMGMQ 526_ MRKAI 531_ MIEVD 536_ DRTEA 541_ YLRVL 546_ QQKVT 551_ ADTQI 556_ VVCLL 561_ SSNRK 566_ DKYDA 571_ IKKYL 576_ CTDCP 581_ TPSQC 586_ VVART 591_ LGKQQ 596_ TVMAI 601_ ATKIA 606_ LQMNC 611_ KMGGE 616_ LWRVD 621_ IPLKL 626_ VMIVG 631_ IDCYH 636_ DMTAG 641_ RRSIA 646_ GFVAS 651_ INEGM 656_ TRWFS 661_ RCIFQ 666_ DRGQE 671_ LVDGL 676_ KVCLQ 681_ AALRA 686_ WNSCN 691_ EYMPS 696_ RIIVY 701_ RDGVG 706_ DGQLK 711_ TLVNY 716_ EVPQF 721_ LDCLK 726_ SIGRG 731_ YNPRL 736_ TVIVV 741_ KKRVN 746_ TRFFA 751_ QSGGR 756_ LQNPL 761_ PGTVI 766_ DVEVT 771_ RPEWY 776_ DFFIV 781_ SQAVR 786_ SGSVS 791_ PTHYN 796_ VIYDN 801_ SGLKP 806_ DHIQR 811_ LTYKL 816_ CHIYY 821_ NWPGV 826_ IRVPA 831_ PCQYA 836_ HKLAF 841_ LVGQS 846_ IHREP 851_ NLSLS 856_NRLYY
1: Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability. Required to sequester RNF8 in the cytoplasm until late spermatogenesis; RNF8 being released upon ubiquitination and degradation of PIWIL1
2: May be a negative developmental regulator (PubMed:12037681, PubMed:16287078)