Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1)
1_MARPV 6_ RGGLG 11_ APRRS 16_ PCLLL 21_ LWLLL 26_ LRLEP 31_ VTAAA 36_ GPRAP 41_ CAAAC 46_ TCAGD 51_ SLDCG 56_ GRGLA 61_ ALPGD 66_ LPSWT 71_ RSLNL 76_ SYNKL 81_ SEIDP 86_ AGFED 91_ LPNLQ 96_ EVYLN 101_ NNELT 106_ AVPSL 111_ GAASS 116_ HVVSL 121_ FLQHN 126_ KIRSV 131_ EGSQL 136_ KAYLS 141_ LEVLD 146_ LSLNN 151_ ITEVR 156_ NTCFP 161_ HGPPI 166_ KELNL 171_ AGNRI 176_ GTLEL 181_ GAFDG 186_ LSRSL 191_ LTLRL 196_ SKNRI 201_ TQLPV 206_ RAFKL 211_ PRLTQ 216_ LDLNR 221_ NRIRL 226_ IEGLT 231_ FQGLN 236_ SLEVL 241_ KLQRN 246_ NISKL 251_ TDGAF 256_ WGLSK 261_ MHVLH 266_ LEYNS 271_ LVEVN 276_ SGSLY 281_ GLTAL 286_ HQLHL 291_ SNNSI 296_ ARIHR 301_ KGWSF 306_ CQKLH 311_ ELVLS 316_ FNNLT 321_ RLDEE 326_ SLAEL 331_ SSLSV 336_ LRLSH 341_ NSISH 346_ IAEGA 351_ FKGLR 356_ SLRVL 361_ DLDHN 366_ EISGT 371_ IEDTS 376_ GAFSG 381_ LDSLS 386_ KLTLF 391_ GNKIK 396_ SVAKR 401_ AFSGL 406_ EGLEH 411_ LNLGG 416_ NAIRS 421_ VQFDA 426_ FVKMK 431_ NLKEL 436_ HISSD 441_ SFLCD 446_ CQLKW 451_ LPPWL 456_ IGRML 461_ QAFVT 466_ ATCAH 471_ PESLK 476_ GQSIF 481_ SVPPE 486_ SFVCD 491_ DFLKP 496_ QIITQ 501_ PETTM 506_ AMVGK 511_ DIRFT 516_ CSAAS 521_ SSSSP 526_ MTFAW 531_ KKDNE 536_ VLTNA 541_ DMENF 546_ VHVHA 551_ QDGEV 556_ MEYTT 561_ ILHLR 566_ QVTFG 571_ HEGRY 576_ QCVIT 581_ NHFGS 586_ TYSHK 591_ ARLTV 596_ NVLPS 601_ FTKTP 606_ HDITI 611_ RTTTM 616_ ARLEC 621_ AATGH 626_ PNPQI 631_ AWQKD 636_ GGTDF 641_ PAARE 646_ RRMHV 651_ MPDDD 656_ VFFIT 661_ DVKID 666_ DAGVY 671_ SCTAQ 676_ NSAGS 681_ ISANA 686_ TLTVL 691_ ETPSL 696_ VVPLE 701_ DRVVS 706_ VGETV 711_ ALQCK 716_ ATGNP 721_ PPRIT 726_ WFKGD 731_ RPLSL 736_ TERHH 741_ LTPDN 746_ QLLVV 751_ QNVVA 756_ EDAGR 761_ YTCEM 766_ SNTLG 771_ TERAH 776_ SQLSV 781_ LPAAG 786_ CRKDG 791_ TTVGI 796_ FTIAV 801_ VSSIV 806_ LTSLV 811_ WVCII 816_ YQTRK 821_ KSEEY 826_ SVTNT 831_ DETVV 836_ PPDVP 841_ SYLSS 846_ QGTLS 851_ DRQET 856_ VVRTE 861_ GGPQA 866_ NGHIE 871_ SNGVC 876_ PRDAS 881_ HFPEP 886_ DTHSV 891_ ACRQP 896_ KLCAG 901_ SAYHK 906_ EPWKA 911_ MEKAE 916_ GTPGP 921_ HKMEH 926_ GGRVV 931_ CSDCN 936_ TEVDC 941_ YSRGQ 946_ AFHPQ 951_ PVSRD 956_ SAQPS 961_ APNGP 966_ EPGGS 971_ DQEHS 976_ PHHQC 981_ SRTAA 986_ GSCPE 991_ CQGSL 996_ YPSNH 1001_ DRMLT 1006_ AVKKK 1011_ PMASL 1016_ DGKGD 1021_ SSWTL 1026_ ARLYH 1031_ PDSTE 1036_ LQPAS 1041_ SLTSG 1046_ SPERA 1051_ EAQYL 1056_ LVSNG 1061_ HLPKA 1066_ CDASP 1071_ ESTPL 1076_ TGQLP 1081_ GKQRV 1086_PLLLA
1: Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation