Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p)
1_MHDAF 6_ EPVPI 11_ LEKLP 16_ LQIDC 21_ LAAWE 26_ EWLLV 31_ GTKQG 36_ HLLLY 41_ RIRKD 46_ VVPAD 51_ VASPE 56_ SGSCN 61_ RFEVT 66_ LEKSN 71_ KNFSK 76_ KIQQI 81_ HVVSQ 86_ FKILV 91_ SLLEN 96_ NIYVH 101_ DLLTF 106_ QQITT 111_ VSKAK 116_ GASLF 121_ TCDLQ 126_ HTETG 131_ EEVLR 136_ MCVAV 141_ KKKLQ 146_ LYFWK 151_ DREFH 156_ ELQGD 161_ FSVPD 166_ VPKSM 171_ AWCEN 176_ SICVG 181_ FKRDY 186_ YLIRV 191_ DGKGS 196_ IKELF 201_ PTGKQ 206_ LEPLV 211_ APLAD 216_ GKVAV 221_ GQDDL 226_ TVVLN 231_ EEGIC 236_ TQKCA 241_ LNWTD 246_ IPVAM 251_ EHQPP 256_ YIIAV 261_ LPRYV 266_ EIRTF 271_ EPRLL 276_ VQSIE 281_ LQRPR 286_ FITSG 291_ GSNII 296_ YVASN 301_ HFVWR 306_ LIPVP 311_ MATQI 316_ QQLLQ 321_ DKQFE 326_ LALQL 331_ AEMKD 336_ DSDSE 341_ KQQQI 346_ HHIKN 351_ LYAFN 356_ LFCQK 361_ RFDES 366_ MQVFA 371_ KLGTD 376_ PTHVM 381_ GLYPD 386_ LLPTD 391_ YRKQL 396_ QYPNP 401_ LPVLS 406_ GAELE 411_ KAHLA 416_ LIDYL 421_ TQKRS 426_ QLVKK 431_ LNDSD 436_ HQSST 441_ SPLME 446_ GTPTI 451_ KSKKK 456_ LLQII 461_ DTTLL 466_ KCYLH 471_ TNVAL 476_ VAPLL 481_ RLENN 486_ HCHIE 491_ ESEHV 496_ LKKAH 501_ KYSEL 506_ IILYE 511_ KKGLH 516_ EKALQ 521_ VLVDQ 526_ SKKAN 531_ SPLKG 536_ HERTV 541_ QYLQH 546_ LGTEN 551_ LHLIF 556_ SYSVW 561_ VLRDF 566_ PEDGL 571_ KIFTE 576_ DLPEV 581_ ESLPR 586_ DRVLG 591_ FLIEN 596_ FKGLA 601_ IPYLE 606_ HIIHV 611_ WEETG 616_ SRFHN 621_ CLIQL 626_ YCEKV 631_ QGLMK 636_ EYLLS 641_ FPAGK 646_ TPVPA 651_ GEEEG 656_ ELGEY 661_ RQKLL 666_ MFLEI 671_ SSYYD 676_ PGRLI 681_ CDFPF 686_ DGLLE 691_ ERALL 696_ LGRMG 701_ KHEQA 706_ LFIYV 711_ HILKD 716_ TRMAE 721_ EYCHK 726_ HYDRN 731_ KDGNK 736_ DVYLS 741_ LLRMY 746_ LSPPS 751_ IHCLG 756_ PIKLE 761_ LLEPK 766_ ANLQA 771_ ALQVL 776_ ELHHS 781_ KLDTT 786_ KALNL 791_ LPANT 796_ QINDI 801_ RIFLE 806_ KVLEE 811_ NAQKK 816_ RFNQV 821_ LKNLL 826_ HAEFL 831_ RVQEE 836_ RILHQ 841_ QVKCI 846_ ITEEK 851_ VCMVC 856_ KKKIG 861_ NSAFA 866_ RYPNG 871_ VVVHY 876_ FCSKE 881_VNPAD
1: Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation
2: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex. This complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (PubMed:11448994, PubMed:23167963, PubMed:23351085). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203, PubMed:37821429)