Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein)
1_MSQPP 6_ PPPPP 11_ LPPPP 16_ PPPEA 21_ PQTPS 26_ SLASA 31_ AASGG 36_ LLKRR 41_ DRRIL 46_ SGSCP 51_ DPKCQ 56_ ARLFF 61_ PASGS 66_ VSIEC 71_ TECGQ 76_ RHEQQ 81_ QLLGV 86_ EEVTD 91_ PDVVL 96_ HNLLR 101_ NALLG 106_ VTGAP 111_ KKNTE 116_ LVKVM 121_ GLSNY 126_ HCKLL 131_ SPILA 136_ RYGMD 141_ KQTGR 146_ AKLLR 151_ DMNQG 156_ ELFDC 161_ ALLGD 166_ RAFLI 171_ EPEHV 176_ NTVGY 181_ GKDRS 186_ GSLLY 191_ LHDTL 196_ EDIKR 201_ ANKSQ 206_ ECLIP 211_ VHVDG 216_ DGHCL 221_ VHAVS 226_ RALVG 231_ RELFW 236_ HALRE 241_ NLKQH 246_ FQQHL 251_ ARYQA 256_ LFHDF 261_ IDAAE 266_ WEDII 271_ NECDP 276_ LFVPP 281_ EGVPL 286_ GLRNI 291_ HIFGL 296_ ANVLH 301_ RPIIL 306_ LDSLS 311_ GMRSS 316_ GDYSA 321_ TFLPG 326_ LIPAE 331_ KCTGK 336_ DGHLN 341_ KPICI 346_ AWSSS 351_ GRNHY 356_ IPLVG 361_ IKGAA 366_ LPKLP 371_ MNLLP 376_ KAWGV 381_ PQDLI 386_ KKYIK 391_ LEEDG 396_ GCVIG 401_ GDRSL 406_ QDKYL 411_ LRLVA 416_ AMEEV 421_ FMDKH 426_ GIHPS 431_ LVADV 436_ HQYFY 441_ RRTGV 446_ IGVQP 451_ EEVTA 456_ AAKKA 461_ VMDNR 466_ LHKCL 471_ LCGAL 476_ SELHV 481_ PPEWL 486_ APGGK 491_ LYNLA 496_ KSTHG 501_ QLRTD 506_ KNYSF 511_ PLNNL 516_ VCSYD 521_ SVKDV 526_ LVPDY 531_ GMSNL 536_ TACNW 541_ CHGTS 546_ VRKVR 551_ GDGSI 556_ VYLDG 561_ DRTNS 566_ RSTGG 571_ KCGCG 576_ FKHFW 581_ DGKEY 586_ DNLPE 591_ AFPIT 596_ LEWGG 601_ RVVRE 606_ TVYWF 611_ QYESD 616_ SSLNS 621_ NVYDV 626_ AMKLV 631_ TKHFP 636_ GEFGS 641_ EILVQ 646_ KVVHT 651_ ILHQT 656_ AKKNP 661_ DDYTP 666_ VNIDG 671_ AHAQR 676_ VGDVQ 681_ GQESE 686_ SQLPT 691_ KIILT 696_ GQKTK 701_ TLHKE 706_ ELNMS 711_ KTERT 716_ IQQNI 721_ TEQAS 726_ VMQKR 731_ KTEKL 736_ KQEQK 741_ GQPRT 746_ VSPST 751_ IRDGP 756_ SSAPA 761_ TPTKA 766_ PYSPT 771_ TSKEK 776_ KIRIT 781_ TNDGR 786_ QSMVT 791_ LKSST 796_ TFFEL 801_ QESIA 806_ REFNI 811_ PPYLQ 816_ CIRYG 821_ FPPKE 826_ LMPPQ 831_ AGMEK 836_ EPVPL 841_ QHGDR 846_ ITIEI 851_ LKSKA 856_ EGGQS 861_ AAAHS 866_ AHTVK 871_ QEDIA 876_ VTGKL 881_ SSKEL 886_ QEQAE 891_ KEMYS 896_ LCLLA 901_ TLMGE 906_ DVWSY 911_ AKGLP 916_ HMFQQ 921_ GGVFY 926_ SIMKK 931_ TMGMA 936_ DGKHC 941_ TFPHL 946_ PGKTF 951_ VYNAS 956_ EDRLE 961_ LCVDA 966_ AGHFP 971_ IGPDV 976_ EDLVK 981_ EAVSQ 986_ VRAEA 991_ TTRSR 996_ ESSPS 1001_ HGLLK 1006_ LGSGG 1011_ VVKKK 1016_ SEQLH 1021_ NVTAF 1026_ QGKGH 1031_ SLGTA 1036_ SGNPH 1041_ LDPRA 1046_ RETSV 1051_ VRKHN 1056_ TGTDF 1061_ SNSST 1066_ KTEPS 1071_ VFTAS 1076_ SSNSE 1081_ LIRIA 1086_ PGVVT 1091_ MRDGR 1096_ QLDPD 1101_ LVEAQ 1106_ RKKLQ 1111_ EMVSS 1116_ IQASM 1121_ DRHLR 1126_ DQSTE 1131_ QSPSD 1136_ LPQRK 1141_ TEVVS 1146_ SSAKS 1151_ GSLQT 1156_ GLPES 1161_ FPLTG 1166_ GTENL 1171_ NTETT 1176_ DGCVA 1181_ DALGA 1186_ AFATR 1191_ SKAQR 1196_ GNSVE 1201_ ELEEM 1206_ DSQDA 1211_ EMTNT 1216_TEPMD
1: Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681)
2: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients