Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1)
1_MTESA 6_ SSTSG 11_ QEFDV 16_ FSVMD 21_ WKDGV 26_ GTLPG 31_ SDLKF 36_ RVNEF 41_ GALEV 46_ ITDEN 51_ EMENV 56_ KKATA 61_ TTTWM 66_ VPTAQ 71_ EAPTS 76_ PPSSR 81_ PVFPP 86_ AYWTS 91_ PPGCP 96_ TVFSE 101_ KTGMP 106_ FRLKD 111_ PVKVE 116_ GLQFC 121_ ENCCQ 126_ YGNVD 131_ ECLSG 136_ GNYCS 141_ QNCAR 146_ HIKDK 151_ DQKEE 156_ RDVEE 161_ DNEEE 166_ DPKCS 171_ RKKKP 176_ KLSLK 181_ ADTKE 186_ DGEER 191_ DDEME 196_ NKQDV 201_ RILRG 206_ SQRAR 211_ RKRRG 216_ DSAVL 221_ KQGLP 226_ PKGKK 231_ AWCWA 236_ SYLEE 241_ EKAVA 246_ VPAKL 251_ FKEHQ 256_ SFPYN 261_ KNGFK 266_ VGMKL 271_ EGVDP 276_ EHQSV 281_ YCVLT 286_ VAEVC 291_ GYRIK 296_ LHFDG 301_ YSDCY 306_ DFWVN 311_ ADALD 316_ IHPVG 321_ WCEKT 326_ GHKLH 331_ PPKGY 336_ KEEEF 341_ NWQTY 346_ LKTCK 351_ AQAAP 356_ KSLFE 361_ NQNIT 366_ VIPSG 371_ FRVGM 376_ KLEAV 381_ DKKNP 386_ SFICV 391_ ATVTD 396_ MVDNR 401_ FLVHF 406_ DNWDE 411_ SYDYW 416_ CEASS 421_ PHIHP 426_ VGWCK 431_ EHRRT 436_ LITPP 441_ GYPNV 446_ KHFSW 451_ DKYLE 456_ ETNSL 461_ PAPAR 466_ AFKVK 471_ PPHGF 476_ QKKMK 481_ LEVVD 486_ KRNPM 491_ FIRVA 496_ TVADT 501_ DDHRV 506_ KVHFD 511_ GWNNC 516_ YDYWI 521_ DADSP 526_ DIHPV 531_ GWCSK 536_ TGHPL 541_ QPPLS 546_ PLELM 551_ EASEH 556_ GGCST 561_ PGCKG 566_ IGHFK 571_ RARHL 576_ GPHSA 581_ ANCPY 586_ SEINL 591_ NKDRI 596_ FPDRL 601_ SGEMP 606_ PASPS 611_ FPRNK 616_ RTDAN 621_ ESSSS 626_ PEIRD 631_ QHADD 636_ VKEDF 641_ EERTE 646_ SEMRT 651_ SHEAR 656_ GAREE 661_ PTVQQ 666_ AQRRS 671_ AVFLS 676_ FKSPI 681_ PCLPL 686_ RWEQQ 691_ SKLLP 696_ TVAGI 701_ PASKV 706_ SKWST 711_ DEVSE 716_ FIQSL 721_ PGCEE 726_ HGKVF 731_ KDEQI 736_ DGEAF 741_ LLMTQ 746_ TDIVK 751_ IMSIK 756_ LGPAL 761_ KIFNS 766_ ILMFK 771_AAEKN
1: Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:29691401, PubMed:30442713). Required for normal maturation of myeloid progenitor cells (By similarity)