Protein fem-1 homolog C (FEM1c) (FEM1-gamma)
1_MDLKT 6_ AVFNA 11_ ARDGK 16_ LRLLT 21_ KLLAS 26_ KSKEE 31_ VSSLI 36_ SEKTN 41_ GATPL 46_ LMAAR 51_ YGHLD 56_ MVEFL 61_ LEQCS 66_ ASIEV 71_ GGSVN 76_ FDGET 81_ IEGAP 86_ PLWAA 91_ SAAGH 96_ LKVVQ 101_ SLLNH 106_ GASVN 111_ NTTLT 116_ NSTPL 121_ RAACF 126_ DGHLE 131_ IVKYL 136_ VEHKA 141_ DLEVS 146_ NRHGH 151_ TCLMI 156_ SCYKG 161_ HKEIA 166_ QYLLE 171_ KGADV 176_ NRKSV 181_ KGNTA 186_ LHDCA 191_ ESGSL 196_ DIMKM 201_ LLMYC 206_ AKMEK 211_ DGYGM 216_ TPLLS 221_ ASVTG 226_ HTNIV 231_ DFLTH 236_ HAQTS 241_ KTERI 246_ NALEL 251_ LGATF 256_ VDKKR 261_ DLLGA 266_ LKYWK 271_ KAMNM 276_ RYSDR 281_ TNIIS 286_ KPVPQ 291_ TLIMA 296_ YDYAK 301_ EVNSA 306_ EELEG 311_ LIADP 316_ DEMRM 321_ QALLI 326_ RERIL 331_ GPSHP 336_ DTSYY 341_ IRYRG 346_ AVYAD 351_ SGNFK 356_ RCINL 361_ WKYAL 366_ DMQQS 371_ NLDPL 376_ SPMTA 381_ SSLLS 386_ FAELF 391_ SFMLQ 396_ DRAKG 401_ LLGTT 406_ VTFDD 411_ LMGIL 416_ CKSVL 421_ EIERA 426_ IKQTQ 431_ CPADP 436_ LQLNK 441_ ALSII 446_ LHLIC 451_ LLEKV 456_ PCTLE 461_ QDHFK 466_ KQTIY 471_ RFLKL 476_ HPRGK 481_ NNFSP 486_ LHLAV 491_ DKNTT 496_ CVGRY 501_ PVCKF 506_ PSLQV 511_ TAILI 516_ ECGAD 521_ VNVRD 526_ SDDNS 531_ PLHIA 536_ ALNNH 541_ PDIMN 546_ LLIKS 551_ GAHFD 556_ ATNLH 561_ KQTAS 566_ DLLDE 571_ KEIAK 576_ NLIQP 581_ INHTT 586_ LQCLA 591_ ARVIV 596_ NHRIY 601_ YKGHI 606_ PEKLE 611_TFVSL
1: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29775578, PubMed:29779948, PubMed:33398168, PubMed:33398170, PubMed:38326650). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29775578, PubMed:29779948, PubMed:33398168, PubMed:33398170). The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (PubMed:33398168, PubMed:33398170, PubMed:38326650). The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). Promotes ubiquitination and degradation of SLBP (PubMed:28118078)