Protein SERAC1 (Serine active site-containing protein 1)
1_MSLAA 6_ YCVIC 11_ CRRIG 16_ TSTSP 21_ PKSGT 26_ HWRDI 31_ RNIIK 36_ FTGSL 41_ ILGGS 46_ LFLTY 51_ EVLAL 56_ KKAVT 61_ LDTQV 66_ VEREK 71_ MKSYI 76_ YVHTV 81_ SLDKG 86_ ENHGI 91_ AWQAR 96_ KELHK 101_ AVRKV 106_ LATSA 111_ KILRN 116_ PFADP 121_ FSTVD 126_ IEDHE 131_ CAVWL 136_ LLRKS 141_ KSDDK 146_ TTRLE 151_ AVREM 156_ SETHH 161_ WHDYQ 166_ YRIIA 171_ QACDP 176_ KTLIG 181_ LARSE 186_ ESDLR 191_ FFLLP 196_ PPLPS 201_ LKEDS 206_ STEEE 211_ LRQLL 216_ ASLPQ 221_ TELDE 226_ CIQYF 231_ TSLAL 236_ SESSQ 241_ SLAAQ 246_ KGGLW 251_ CFGGN 256_ GLPYA 261_ ESFGE 266_ VPSAT 271_ VEMFC 276_ LEAIV 281_ KHSEI 286_ STHCD 291_ KIEAN 296_ GGLQL 301_ LQRLY 306_ RLHKD 311_ CPKVQ 316_ RNIMR 321_ VIGNM 326_ ALNEH 331_ LHSSI 336_ VRSGW 341_ VSIMA 346_ EAMKS 351_ PHIME 356_ SSHAA 361_ RILAN 366_ LDRET 371_ VQEKY 376_ QDGVY 381_ VLHPQ 386_ YRTSQ 391_ PIKAD 396_ VLFIH 401_ GLMGA 406_ AFKTW 411_ RQQDS 416_ EQAVI 421_ EKPME 426_ DEDRY 431_ TTCWP 436_ KTWLA 441_ KDCPA 446_ LRIIS 451_ VEYDT 456_ SLSDW 461_ RARCP 466_ MERKS 471_ IAFRS 476_ NELLR 481_ KLRAA 486_ GVGDR 491_ PVVWI 496_ SHSMG 501_ GLLVK 506_ KMLLE 511_ ASTKP 516_ EMSTV 521_ INNTR 526_ GIIFY 531_ SVPHH 536_ GSRLA 541_ EYSVN 546_ IRYLL 551_ FPSLE 556_ VKELS 561_ KDSPA 566_ LKTLQ 571_ DDFLE 576_ FAKDK 581_ NFQVL 586_ NFVET 591_ LPTYI 596_ GSMIK 601_ LHVVP 606_ VESAD 611_ LGIGD 616_ LIPVD 621_ VNHLN 626_ ICKPK 631_ KKDAF 636_ LYQRT 641_ LQFIR 646_EALAK
1: Facilitates the transport of serine from the cytosol to the mitochondria by interacting with and stabilizing Sideroflexin-1 (SFXN1), a mitochondrial serine transporter, playing a fundamental role in the one-carbon cycle responsible for the synthesis of nucleotides needed for mitochondrial DNA replication (PubMed:35235340). Plays an important role in the phosphatidylglycerol (PG) remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking (PubMed:22683713). Specifically involved in the exchange of the sn-1 acyl chain from PG 16:0/18:1(9Z) (also known as 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)) to PG 18:0/18:1(9Z) (also known as 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)), a step needed in the bis(monoacylglycerol)phosphate biosynthetic pathway (PubMed:22683713). May have acyltransferase activity although the mechanism for PG remodeling has not been determined (PubMed:22683713)